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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1998-7-9
|
| pubmed:databankReference | |
| pubmed:abstractText |
The C. elegans gene ced-7 functions in the engulfment of cell corpses during programmed cell death. We report that the CED-7 protein has sequence similarity to ABC transporters, is broadly expressed during embryogenesis, and is localized to the plasma membrane. Mosaic analysis revealed that ced-7 functions in both dying cells and engulfing cells during the engulfment process. We propose that CED-7 functions to translocate molecules that mediate homotypic adhesion between the cell surfaces of the dying and engulfing cells. Like CED-7, the mammalian ABC transporter ABC1 has been implicated in the engulfment of cell corpses, suggesting that CED-7 and ABC1 may be functionally similar and that the molecular mechanism underlying cell corpse engulfment during programmed cell death may be conserved from nematodes to mammals.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0092-8674
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
12
|
| pubmed:volume |
93
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
951-60
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9635425-ATP-Binding Cassette Transporters,
pubmed-meshheading:9635425-Amino Acid Sequence,
pubmed-meshheading:9635425-Animals,
pubmed-meshheading:9635425-Apoptosis,
pubmed-meshheading:9635425-Caenorhabditis elegans,
pubmed-meshheading:9635425-Caenorhabditis elegans Proteins,
pubmed-meshheading:9635425-Cell Membrane,
pubmed-meshheading:9635425-Chromosome Mapping,
pubmed-meshheading:9635425-Cloning, Molecular,
pubmed-meshheading:9635425-Gene Expression Regulation, Developmental,
pubmed-meshheading:9635425-Genes, Helminth,
pubmed-meshheading:9635425-Gonads,
pubmed-meshheading:9635425-Molecular Sequence Data,
pubmed-meshheading:9635425-Mosaicism,
pubmed-meshheading:9635425-Neurons, Afferent,
pubmed-meshheading:9635425-Phagocytosis,
pubmed-meshheading:9635425-Sequence Analysis, DNA,
pubmed-meshheading:9635425-Sequence Homology, Amino Acid
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters.
|
| pubmed:affiliation |
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|