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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-8-27
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pubmed:databankReference |
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pubmed:abstractText |
Myotrophin is a 12.5 kDa protein that appears to have a key role in the initiation of cardiac hypertrophy, a central process in many heart diseases. Myotrophin primarily comprises ankyrin-like (ANK) repeats, the 33 amino acid motifs involved in a wide range of protein-protein interactions. As a first step in the structure-based search for cardiac hypertrophy antagonists and in order to gain insight into the molecular basis of action of the ubiquitous and multifunctional ANK repeat motif, we have determined the solution structure of myotrophin using multidimensional heteronuclear NMR spectroscopy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0969-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
619-26
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9634699-Amino Acid Sequence,
pubmed-meshheading:9634699-Ankyrin Repeat,
pubmed-meshheading:9634699-Apoptosis Regulatory Proteins,
pubmed-meshheading:9634699-Cardiomegaly,
pubmed-meshheading:9634699-Carrier Proteins,
pubmed-meshheading:9634699-Growth Substances,
pubmed-meshheading:9634699-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:9634699-Molecular Sequence Data,
pubmed-meshheading:9634699-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:9634699-Solutions
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pubmed:year |
1998
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pubmed:articleTitle |
The structural basis of ankyrin-like repeat function as revealed by the solution structure of myotrophin.
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pubmed:affiliation |
Structural Biology Program, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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