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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-8-13
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pubmed:abstractText |
Molecular geneticists are developing the third-generation human genome map with single-nucleotide polymorphisms (SNPs), which can be assayed via chip-based microarrays. One use of these SNP markers is the ability to locate loci that may be responsible for complex traits, via linkage/linkage-disequilibrium analysis. In this communication, we describe a semiparametric method for combined linkage/linkage-disequilibrium analysis using SNP markers. Asymptotic results are obtained for the estimated parameters, and the finite-sample properties are evaluated via a simulation study. We also applied this technique to a simulated genome-scan experiment for mapping a complex trait with two major genes. This experiment shows that separate linkage and linkage-disequilibrium analyses correctly detected the signals of both major genes; but the rates of false-positive signals seem high. When linkage and linkage-disequilibrium signals were combined, the analysis yielded much stronger and clearer signals for the presence of two major genes than did two separate analyses.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-1609796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-17776803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-2049513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-3664638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-7668272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-7726179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-7847388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-8037216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-8091227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-8116627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-8666377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-8751872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-8849452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-9199574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-9288093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-9311749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-9311750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-9391823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-9582121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9634510-9632166
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0002-9297
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
225-40
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9634510-Biosensing Techniques,
pubmed-meshheading:9634510-Chromosome Mapping,
pubmed-meshheading:9634510-Genetic Diseases, Inborn,
pubmed-meshheading:9634510-Genetic Linkage,
pubmed-meshheading:9634510-Genetic Markers,
pubmed-meshheading:9634510-Genome, Human,
pubmed-meshheading:9634510-Genotype,
pubmed-meshheading:9634510-Humans,
pubmed-meshheading:9634510-Linkage Disequilibrium,
pubmed-meshheading:9634510-Models, Genetic,
pubmed-meshheading:9634510-Nucleotides,
pubmed-meshheading:9634510-Pedigree,
pubmed-meshheading:9634510-Polymorphism, Genetic
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pubmed:year |
1998
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pubmed:articleTitle |
Mapping of complex traits by single-nucleotide polymorphisms.
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pubmed:affiliation |
Quantitative Genetic Epidemiology Group, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. lzhao@fhcrc.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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