| pubmed-article:9632524 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9632524 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:9632524 | lifeskim:mentions | umls-concept:C0115305 | lld:lifeskim |
| pubmed-article:9632524 | lifeskim:mentions | umls-concept:C0214743 | lld:lifeskim |
| pubmed-article:9632524 | lifeskim:mentions | umls-concept:C0023516 | lld:lifeskim |
| pubmed-article:9632524 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:9632524 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:9632524 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:9632524 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9632524 | lifeskim:mentions | umls-concept:C1272706 | lld:lifeskim |
| pubmed-article:9632524 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9632524 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9632524 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:9632524 | pubmed:dateCreated | 1998-7-15 | lld:pubmed |
| pubmed-article:9632524 | pubmed:abstractText | Leukocyte extravasation is governed by the endothelium, expressing a defined pattern of adhesion molecules in response to inflammatory stimuli. Among them, E-selectin, which is expressed in response to interleukin 1 (IL-1) or tumour necrosis factor alpha (TNF-alpha), provides rolling adhesion of the circulating leukocytes, a transient and reversible interaction that initiates leukocyte extravasation. In our experiments, E-selectin expression culminated after 4 to 6 h and declined thereafter. After 24 h a considerable amount of E-selectin was presented, reflecting its continuous expression in different inflammatory skin disorders. After preincubation of the endothelial cells with TNF-alpha together with IL-4 or IL-13, E-selectin mRNA transcription and protein expression were markedly reduced at 8 h and almost abolished at 20 h. In contrast, early E-selectin expression between 2 to 6 h was not significantly impaired. In a rotating adherence assay that mimics physiological shear forces in circulation, preincubation of the endothelial cells with TNF-alpha for 4 and 20 h induced similar adherence of neutrophils, which was largely E-selectin dependent. According to the modified expression kinetics of E-selectin in the presence of IL-4 of IL-13 rolling adhesion was unimpaired at 4 h but significantly diminished after 20 h of preincubation. Similar results were obtained with clones of the cutaneous T cell lymphoma cell line HUT78 highly expressing the E-selectin ligand cutaneous lymphocyte-associated Ag. Together, these data suggest that IL-4 and IL-13 control the rolling adhesion by limiting the period of the induced E-selectin expression and may thereby confine the acute phase of leukocyte emigration. | lld:pubmed |
| pubmed-article:9632524 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9632524 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632524 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9632524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632524 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9632524 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9632524 | pubmed:issn | 1043-4666 | lld:pubmed |
| pubmed-article:9632524 | pubmed:author | pubmed-author:MosesSS | lld:pubmed |
| pubmed-article:9632524 | pubmed:author | pubmed-author:WeberLL | lld:pubmed |
| pubmed-article:9632524 | pubmed:author | pubmed-author:EtterHH | lld:pubmed |
| pubmed-article:9632524 | pubmed:author | pubmed-author:EugsterH PHP | lld:pubmed |
| pubmed-article:9632524 | pubmed:author | pubmed-author:AlthausRR | lld:pubmed |
| pubmed-article:9632524 | pubmed:author | pubmed-author:Santamaria-Ba... | lld:pubmed |
| pubmed-article:9632524 | pubmed:copyrightInfo | Copyright 1998 Academic Press Limited. | lld:pubmed |
| pubmed-article:9632524 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9632524 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:9632524 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9632524 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9632524 | pubmed:pagination | 395-403 | lld:pubmed |
| pubmed-article:9632524 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:9632524 | pubmed:meshHeading | pubmed-meshheading:9632524-... | lld:pubmed |
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| pubmed-article:9632524 | pubmed:meshHeading | pubmed-meshheading:9632524-... | lld:pubmed |
| pubmed-article:9632524 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9632524 | pubmed:articleTitle | IL-4 and IL-13 downregulate rolling adhesion of leukocytes to IL-1 or TNF-alpha-activated endothelial cells by limiting the interval of E-selectin expression. | lld:pubmed |
| pubmed-article:9632524 | pubmed:affiliation | Institute of Toxicology of the Swiss Federal Institute of Technology and University of Zurich, CH-8603 Schwerzenbach, Switzerland. | lld:pubmed |
| pubmed-article:9632524 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9632524 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9632524 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9632524 | lld:pubmed |
