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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5371
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pubmed:dateCreated |
1998-7-15
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pubmed:abstractText |
Signaling pathways that stabilize interleukin-2 (IL-2) messenger RNA (mRNA) in activated T cells were examined. IL-2 mRNA contains at least two cis elements that mediated its stabilization in response to different signals, including activation of c-Jun amino-terminal kinase (JNK). This response was mediated through a cis element encompassing the 5' untranslated region (UTR) and the beginning of the coding region. IL-2 transcripts lacking this 5' element no longer responded to JNK activation but were still responsive to other signals generated during T cell activation, which were probably sensed through the 3' UTR. Thus, multiple elements within IL-2 mRNA modulate its stability in a combinatorial manner, and the JNK pathway controls turnover as well as synthesis of IL-2 mRNA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-(4-fluorophenyl)-2-(4-hydroxypheny...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Calcimycin,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
280
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1945-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9632395-Antigens, CD28,
pubmed-meshheading:9632395-Antigens, CD3,
pubmed-meshheading:9632395-Calcimycin,
pubmed-meshheading:9632395-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9632395-Cyclosporine,
pubmed-meshheading:9632395-Enzyme Activation,
pubmed-meshheading:9632395-Enzyme Inhibitors,
pubmed-meshheading:9632395-Gene Expression Regulation,
pubmed-meshheading:9632395-Humans,
pubmed-meshheading:9632395-Imidazoles,
pubmed-meshheading:9632395-Interleukin-2,
pubmed-meshheading:9632395-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:9632395-Jurkat Cells,
pubmed-meshheading:9632395-Lymphocyte Activation,
pubmed-meshheading:9632395-MAP Kinase Kinase 1,
pubmed-meshheading:9632395-MAP Kinase Kinase 7,
pubmed-meshheading:9632395-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:9632395-Mitogen-Activated Protein Kinases,
pubmed-meshheading:9632395-Protein Kinases,
pubmed-meshheading:9632395-Protein-Serine-Threonine Kinases,
pubmed-meshheading:9632395-Protein-Tyrosine Kinases,
pubmed-meshheading:9632395-Pyridines,
pubmed-meshheading:9632395-RNA, Messenger,
pubmed-meshheading:9632395-Signal Transduction,
pubmed-meshheading:9632395-T-Lymphocytes,
pubmed-meshheading:9632395-Tetradecanoylphorbol Acetate,
pubmed-meshheading:9632395-Transgenes,
pubmed-meshheading:9632395-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
1998
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pubmed:articleTitle |
Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway.
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pubmed:affiliation |
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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