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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1998-8-24
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pubmed:abstractText |
Astrocytes express phospholipase C (PLC)-coupled metabotropic glutamate receptors (only mGluR5 is detectable) and adenylyl cyclase (AC)-linked beta-adrenergic receptors. Calcium-sensitive effector enzymes are associated with these signal transduction pathways, but the relevant calcium compartments involved were found to be different. mGluR5-linked PLC responded primarily to extracellular Ca2+, suggesting a close spatial relation between the enzyme and Ca2+ entry channels. On the other hand, the calcium-inhibited AC associated with beta-adrenergic receptors was sensitive to intracellular Ca2+ selectively accessible to intracellular Ca2+ chelation. Furthermore, cAMP formation induced by direct activation of AC by forskolin was less responsive to intracellular Ca2+ chelation than that evoked by the receptor-activated AC, raising the possibility of selective access of the receptor to a pool of calcium-inhibited AC and/or the calcium modulation of some components of the coupling pathway.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,2-bis(2-aminophenoxy)ethane-N,N,N'...,
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Chelating Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Egtazic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Ionomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositols,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Type C Phospholipases,
http://linkedlifedata.com/resource/pubmed/chemical/metabotropic glutamate receptor 5
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1397-401
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9631436-Adenylate Cyclase,
pubmed-meshheading:9631436-Analysis of Variance,
pubmed-meshheading:9631436-Animals,
pubmed-meshheading:9631436-Animals, Newborn,
pubmed-meshheading:9631436-Astrocytes,
pubmed-meshheading:9631436-Calcium,
pubmed-meshheading:9631436-Cells, Cultured,
pubmed-meshheading:9631436-Chelating Agents,
pubmed-meshheading:9631436-Cyclic AMP,
pubmed-meshheading:9631436-Egtazic Acid,
pubmed-meshheading:9631436-Ionomycin,
pubmed-meshheading:9631436-Neocortex,
pubmed-meshheading:9631436-Phosphatidylinositols,
pubmed-meshheading:9631436-Rats,
pubmed-meshheading:9631436-Rats, Sprague-Dawley,
pubmed-meshheading:9631436-Receptors, Adrenergic, beta,
pubmed-meshheading:9631436-Receptors, Metabotropic Glutamate,
pubmed-meshheading:9631436-Type C Phospholipases
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pubmed:year |
1998
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pubmed:articleTitle |
Receptor-coupled phospholipase C and adenylyl cyclase function with different calcium pools in astrocytes.
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pubmed:affiliation |
Institute for Brain Aging and Dementia, University of California, Irvine 92697-4540, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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