| pubmed-article:9630228 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9630228 | lifeskim:mentions | umls-concept:C1708800 | lld:lifeskim |
| pubmed-article:9630228 | lifeskim:mentions | umls-concept:C0108554 | lld:lifeskim |
| pubmed-article:9630228 | lifeskim:mentions | umls-concept:C1367675 | lld:lifeskim |
| pubmed-article:9630228 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:9630228 | lifeskim:mentions | umls-concept:C1150582 | lld:lifeskim |
| pubmed-article:9630228 | lifeskim:mentions | umls-concept:C0887839 | lld:lifeskim |
| pubmed-article:9630228 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9630228 | pubmed:dateCreated | 1998-7-6 | lld:pubmed |
| pubmed-article:9630228 | pubmed:abstractText | T cell activation requires the import of NF-AT transcription factors to the nucleus, a process promoted by calcineurin-dependent dephosphorylation and inhibited by poorly understood protein kinases. Here, we report the identification of two protein kinases that oppose NF-AT4 nuclear import. Casein kinase Ialpha directly binds and phosphorylates NF-AT4, resulting in the inhibiton of NF-AT4 nuclear translocation. MEKK1 indirectly suppresses NF-AT4 nuclear import by stabilizing the interaction between NF-AT4 and CKIalpha. CKIalpha thus acts to establish an intramolecular masking of the nuclear location signal on NF-AT4, while MEKK1 augments this mechanism, and may further provide a link to signal transduction pathways regulating NF-AT4. | lld:pubmed |
| pubmed-article:9630228 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9630228 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9630228 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9630228 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9630228 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9630228 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9630228 | pubmed:month | May | lld:pubmed |
| pubmed-article:9630228 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:9630228 | pubmed:author | pubmed-author:WagnerGG | lld:pubmed |
| pubmed-article:9630228 | pubmed:author | pubmed-author:FerraraPP | lld:pubmed |
| pubmed-article:9630228 | pubmed:author | pubmed-author:YanoTT | lld:pubmed |
| pubmed-article:9630228 | pubmed:author | pubmed-author:PriceRR | lld:pubmed |
| pubmed-article:9630228 | pubmed:author | pubmed-author:ZinRR | lld:pubmed |
| pubmed-article:9630228 | pubmed:author | pubmed-author:ShibasakiFF | lld:pubmed |
| pubmed-article:9630228 | pubmed:author | pubmed-author:GuillemotJ... | lld:pubmed |
| pubmed-article:9630228 | pubmed:author | pubmed-author:McKeonFF | lld:pubmed |
| pubmed-article:9630228 | pubmed:author | pubmed-author:DötschVV | lld:pubmed |
| pubmed-article:9630228 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9630228 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:9630228 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:9630228 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9630228 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9630228 | pubmed:pagination | 851-61 | lld:pubmed |
| pubmed-article:9630228 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9630228 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9630228 | pubmed:articleTitle | Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. | lld:pubmed |
| pubmed-article:9630228 | pubmed:affiliation | Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA. | lld:pubmed |
| pubmed-article:9630228 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9630228 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9630228 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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