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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-7-6
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pubmed:abstractText |
T cell activation requires the import of NF-AT transcription factors to the nucleus, a process promoted by calcineurin-dependent dephosphorylation and inhibited by poorly understood protein kinases. Here, we report the identification of two protein kinases that oppose NF-AT4 nuclear import. Casein kinase Ialpha directly binds and phosphorylates NF-AT4, resulting in the inhibiton of NF-AT4 nuclear translocation. MEKK1 indirectly suppresses NF-AT4 nuclear import by stabilizing the interaction between NF-AT4 and CKIalpha. CKIalpha thus acts to establish an intramolecular masking of the nuclear location signal on NF-AT4, while MEKK1 augments this mechanism, and may further provide a link to signal transduction pathways regulating NF-AT4.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Casein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Serum-Free,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/NFATC Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Localization Signals,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
851-61
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9630228-Amino Acid Sequence,
pubmed-meshheading:9630228-Biological Transport,
pubmed-meshheading:9630228-Blotting, Western,
pubmed-meshheading:9630228-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9630228-Casein Kinases,
pubmed-meshheading:9630228-Cell Nucleus,
pubmed-meshheading:9630228-Cells, Cultured,
pubmed-meshheading:9630228-Chromatography, Affinity,
pubmed-meshheading:9630228-Culture Media, Serum-Free,
pubmed-meshheading:9630228-DNA-Binding Proteins,
pubmed-meshheading:9630228-Fluorescent Antibody Technique,
pubmed-meshheading:9630228-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:9630228-Mitogen-Activated Protein Kinases,
pubmed-meshheading:9630228-Models, Biological,
pubmed-meshheading:9630228-Molecular Sequence Data,
pubmed-meshheading:9630228-NFATC Transcription Factors,
pubmed-meshheading:9630228-Nuclear Localization Signals,
pubmed-meshheading:9630228-Nuclear Proteins,
pubmed-meshheading:9630228-Phosphorylation,
pubmed-meshheading:9630228-Precipitin Tests,
pubmed-meshheading:9630228-Protein Binding,
pubmed-meshheading:9630228-Protein Kinases,
pubmed-meshheading:9630228-Protein-Serine-Threonine Kinases,
pubmed-meshheading:9630228-Protein-Tyrosine Kinases,
pubmed-meshheading:9630228-Signal Transduction,
pubmed-meshheading:9630228-Transcription Factors
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pubmed:year |
1998
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pubmed:articleTitle |
Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1.
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pubmed:affiliation |
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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