| pubmed-article:9629242 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9629242 | lifeskim:mentions | umls-concept:C0021757 | lld:lifeskim |
| pubmed-article:9629242 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:9629242 | lifeskim:mentions | umls-concept:C0080096 | lld:lifeskim |
| pubmed-article:9629242 | pubmed:dateCreated | 1998-7-9 | lld:pubmed |
| pubmed-article:9629242 | pubmed:abstractText | We have previously demonstrated that interleukin 3 (IL-3) has a neurotrophic effect on central cholinergic neurons and have demonstrated the presence of IL-3 receptor (IL-3R)beta subunits in septal cholinergic neurons by reverse-transcribed polymerase chain reaction (RT-PCR) and immunohistochemistry. In order to confirm that the expressed IL-3R is functional, we conducted experiments to show an alpha subunit of IL-3R. The alpha subunit was clearly demonstrated by RT-PCR in the central cholinergic neuronal hybrid cell line SN6, but not in its mother cell line N18TG2, and the expression was slightly upregulated after IL-3 treatment. Choline acetyltransferase and vesicular acetylcholine transporter mRNAs were significantly increased in SN6 after treatment with IL-3. Immunohistochemically, IL-3R alpha-positive cells were mainly present in the medial septal and basal forebrain region, and the stained cells were similar to choline acetyltransferase-positive cells in shape and distribution. The IL-3R alpha-positive cells slightly increased two days after fimbria-fornix transection and decreased seven days after. These findings suggest that functional IL-3 receptors are expressed in the central cholinergic neurons and contribute to some physiological roles such as the differentiation and maintenance of these neurons. | lld:pubmed |
| pubmed-article:9629242 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9629242 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9629242 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9629242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9629242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9629242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9629242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9629242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9629242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9629242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9629242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9629242 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9629242 | pubmed:month | May | lld:pubmed |
| pubmed-article:9629242 | pubmed:issn | 0077-8923 | lld:pubmed |
| pubmed-article:9629242 | pubmed:author | pubmed-author:TabiraTT | lld:pubmed |
| pubmed-article:9629242 | pubmed:author | pubmed-author:KonishiYY | lld:pubmed |
| pubmed-article:9629242 | pubmed:author | pubmed-author:ShirabeTT | lld:pubmed |
| pubmed-article:9629242 | pubmed:author | pubmed-author:ChuiD HDH | lld:pubmed |
| pubmed-article:9629242 | pubmed:author | pubmed-author:LinL LLL | lld:pubmed |
| pubmed-article:9629242 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9629242 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9629242 | pubmed:volume | 840 | lld:pubmed |
| pubmed-article:9629242 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9629242 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9629242 | pubmed:pagination | 107-16 | lld:pubmed |
| pubmed-article:9629242 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9629242 | pubmed:meshHeading | pubmed-meshheading:9629242-... | lld:pubmed |
| pubmed-article:9629242 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9629242 | pubmed:articleTitle | Interleukin-3 and interleukin-3 receptors in the brain. | lld:pubmed |
| pubmed-article:9629242 | pubmed:affiliation | Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Tokyo, Japan. tabira@ncnaxp.ncnp.go.jp | lld:pubmed |
| pubmed-article:9629242 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9629242 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3562 | entrezgene:pubmed | pubmed-article:9629242 | lld:entrezgene |
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