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rdf:type |
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lifeskim:mentions |
umls-concept:C0017547,
umls-concept:C0084913,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0600253,
umls-concept:C1332320,
umls-concept:C1332713,
umls-concept:C1415831,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C2239666
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pubmed:issue |
6
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|
pubmed:dateCreated |
1998-7-13
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pubmed:databankReference |
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pubmed:abstractText |
Ubiquitin-conjugating enzymes (UBC) catalyze the covalent attachment of ubiquitin to target proteins and are distinguished by the presence of a UBC domain required for catalysis. Previously identified members of this enzyme family are small proteins and function primarily in selective proteolysis pathways. Here we describe BRUCE (BIR repeat containing ubiquitin-conjugating enzyme), a giant (528-kD) ubiquitin-conjugating enzyme from mice. BRUCE is membrane associated and localizes to the Golgi compartment and the vesicular system. Remarkably, in addition to being an active ubiquitin-conjugating enzyme, BRUCE bears a baculovirus inhibitor of apoptosis repeat (BIR) motif, which to this date has been exclusively found in apoptosis inhibitors of the IAP-related protein family. The BIR motifs of IAP proteins are indispensable for their anti-cell death activity and are thought to function through protein-protein interaction. This suggests that BRUCE may combine properties of IAP-like proteins and ubiquitin-conjugating enzymes and indicates that the family of IAP-like proteins is structurally and functionally more diverse than previously expected.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-1326082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-1336336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-1378265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-17708972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-17708991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-1962198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-7553848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-7569933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-7675111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-7693962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-7708685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-7800044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-7813013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-7923371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-8139034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-8396728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-8436587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-8491209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-8548810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-8548811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-8552191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-8557188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-8576256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-8576257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-8861955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-8939846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-8982460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-9111355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-9230442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-9233772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-9256286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-9294184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-9341106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-9384571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-9388185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-9390553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-9390557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-9391073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-9393848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-9422506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-9435231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9628897-9545234
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0021-9525
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
141
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1415-22
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9628897-Amino Acid Sequence,
pubmed-meshheading:9628897-Animals,
pubmed-meshheading:9628897-Base Sequence,
pubmed-meshheading:9628897-DNA, Complementary,
pubmed-meshheading:9628897-Gene Expression,
pubmed-meshheading:9628897-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:9628897-Intracellular Membranes,
pubmed-meshheading:9628897-Ligases,
pubmed-meshheading:9628897-Membrane Proteins,
pubmed-meshheading:9628897-Mice,
pubmed-meshheading:9628897-Molecular Sequence Data,
pubmed-meshheading:9628897-PC12 Cells,
pubmed-meshheading:9628897-Rats,
pubmed-meshheading:9628897-Sequence Homology, Amino Acid,
pubmed-meshheading:9628897-Ubiquitin-Conjugating Enzymes,
pubmed-meshheading:9628897-Viral Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors.
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