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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0007102,
umls-concept:C0017262,
umls-concept:C0033684,
umls-concept:C0185117,
umls-concept:C0210994,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0879392,
umls-concept:C0919458,
umls-concept:C1413246,
umls-concept:C1510470,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1704873,
umls-concept:C2911684
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|
pubmed:issue |
6
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|
pubmed:dateCreated |
1998-8-27
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|
pubmed:abstractText |
It is important to detect genes that may be good prognostic markers for colon cancer patients. With this in mind, we identified the motility related protein-1 (MRP1/CD9) gene in human colon tissues. The aim of this study was to clarify the significance of MRP1/CD9 gene expression in human colon cancers. We performed the differential mRNA display technique between tumor/normal paired samples of the colon and identified MRP1/CD9. Eighty-two surgical specimens of primary colorectal cancer were analyzed by means of reverse transcription-PCR for the MRP1/CD9 gene. Its expression status and clinicopathological variables were analyzed univariately and multivariately. The MRP1/ CD9 mRNA expression was positive in 56 cases and negative in 26 cases. The MRP1/CD9 negative cases showed a significantly higher frequency of venous-vessel invasion and liver metastasis, or a worse prognosis than the MRP1/CD9 positive cases (P < 0.05). Multivariate analysis with the Cox regression model disclosed that MRP1/CD9 expression was an independent prognostic factor distinct from the lymph node status. The findings imply that the study of MRP1/CD9 expression may be useful for predicting prognosis of patients with colorectal cancer.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1507-10
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9626469-Aged,
pubmed-meshheading:9626469-Analysis of Variance,
pubmed-meshheading:9626469-Antigens, CD,
pubmed-meshheading:9626469-Antigens, CD9,
pubmed-meshheading:9626469-Colonic Neoplasms,
pubmed-meshheading:9626469-Female,
pubmed-meshheading:9626469-Follow-Up Studies,
pubmed-meshheading:9626469-Humans,
pubmed-meshheading:9626469-Male,
pubmed-meshheading:9626469-Membrane Glycoproteins,
pubmed-meshheading:9626469-Multivariate Analysis,
pubmed-meshheading:9626469-Polymerase Chain Reaction,
pubmed-meshheading:9626469-RNA, Messenger,
pubmed-meshheading:9626469-Rectal Neoplasms,
pubmed-meshheading:9626469-Survival Analysis,
pubmed-meshheading:9626469-Time Factors,
pubmed-meshheading:9626469-Transcription, Genetic
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pubmed:year |
1998
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pubmed:articleTitle |
Motility related protein 1 (MRP1/CD9) expression in colon cancer.
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pubmed:affiliation |
Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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