| pubmed-article:9626329 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9626329 | lifeskim:mentions | umls-concept:C0038836 | lld:lifeskim |
| pubmed-article:9626329 | lifeskim:mentions | umls-concept:C0073898 | lld:lifeskim |
| pubmed-article:9626329 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:9626329 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9626329 | pubmed:dateCreated | 1998-7-2 | lld:pubmed |
| pubmed-article:9626329 | pubmed:abstractText | The nitric oxide (NO)-dependent S-nitrosation of thiols to generate S-nitrosothiols has been proposed as an important pathway for the metabolism of NO in vivo. Although it has been suggested that these S-nitrosated compounds are resistant to decomposition by reactive oxygen metabolites (ROMs), very little information is available regarding the interaction between S-nitrosothiols and ROMs. We found that S-nitrosoglutathione (GSNO) rapidly reacted with O2- to generate glutathione disulfide and equimolar quantities of nitrite and nitrate. The reaction was second order with respect of GSNO and first order with respect of O2- with a rate equation of -d[GSNO]/dt = 2k3[GSNO]2[O2-], where k3 = 3 - 6 x 10(8) M-2s-1. In addition, the reaction of GSNO with O2- generated a strong oxidant as an intermediate capable of oxidizing dihydrorhodamine in the absence of the apparent generation of NO. We conclude that O2- may act as a physiological modulator of S-nitrosation reactions by directly promoting the decomposition of S-nitrosothiols. | lld:pubmed |
| pubmed-article:9626329 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9626329 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9626329 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9626329 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9626329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9626329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9626329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9626329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9626329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9626329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9626329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9626329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9626329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9626329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9626329 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9626329 | pubmed:month | May | lld:pubmed |
| pubmed-article:9626329 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:9626329 | pubmed:author | pubmed-author:GrishamM BMB | lld:pubmed |
| pubmed-article:9626329 | pubmed:author | pubmed-author:Jourd'heuilDD | lld:pubmed |
| pubmed-article:9626329 | pubmed:author | pubmed-author:WinkD ADA | lld:pubmed |
| pubmed-article:9626329 | pubmed:author | pubmed-author:LaiB TBT | lld:pubmed |
| pubmed-article:9626329 | pubmed:author | pubmed-author:LarouxF SFS | lld:pubmed |
| pubmed-article:9626329 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9626329 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:9626329 | pubmed:volume | 246 | lld:pubmed |
| pubmed-article:9626329 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9626329 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9626329 | pubmed:pagination | 525-30 | lld:pubmed |
| pubmed-article:9626329 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9626329 | pubmed:meshHeading | pubmed-meshheading:9626329-... | lld:pubmed |
| pubmed-article:9626329 | pubmed:meshHeading | pubmed-meshheading:9626329-... | lld:pubmed |
| pubmed-article:9626329 | pubmed:meshHeading | pubmed-meshheading:9626329-... | lld:pubmed |
| pubmed-article:9626329 | pubmed:meshHeading | pubmed-meshheading:9626329-... | lld:pubmed |
| pubmed-article:9626329 | pubmed:meshHeading | pubmed-meshheading:9626329-... | lld:pubmed |
| pubmed-article:9626329 | pubmed:meshHeading | pubmed-meshheading:9626329-... | lld:pubmed |
| pubmed-article:9626329 | pubmed:meshHeading | pubmed-meshheading:9626329-... | lld:pubmed |
| pubmed-article:9626329 | pubmed:meshHeading | pubmed-meshheading:9626329-... | lld:pubmed |
| pubmed-article:9626329 | pubmed:meshHeading | pubmed-meshheading:9626329-... | lld:pubmed |
| pubmed-article:9626329 | pubmed:meshHeading | pubmed-meshheading:9626329-... | lld:pubmed |
| pubmed-article:9626329 | pubmed:meshHeading | pubmed-meshheading:9626329-... | lld:pubmed |
| pubmed-article:9626329 | pubmed:meshHeading | pubmed-meshheading:9626329-... | lld:pubmed |
| pubmed-article:9626329 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9626329 | pubmed:articleTitle | The reaction of S-nitrosoglutathione with superoxide. | lld:pubmed |
| pubmed-article:9626329 | pubmed:affiliation | Department of Molecular and Cellular Physiology, Louisiana State University Medical Center, Shreveport 71130, USA. | lld:pubmed |
| pubmed-article:9626329 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9626329 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9626329 | lld:pubmed |
