|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1998-7-1
|
|
pubmed:abstractText |
Standard therapies of head and neck squamous cell carcinoma (HNSCC) often cause profound morbidity and have not significantly improved survival over the last 30 years. Preclinical studies showed that adenoviral vector delivery of the wild-type p53 gene reduced tumor growth in mouse xenograft models. Our purpose was to ascertain the safety and therapeutic potential of adenoviral (Ad)-p53 in advanced HNSCC.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0732-183X
|
|
pubmed:author |
pubmed-author:BrusoPP,
pubmed-author:ClaymanG LGL,
pubmed-author:DAWH THT,
pubmed-author:FrederickMM,
pubmed-author:GinsbergLL,
pubmed-author:GoepfertHH,
pubmed-author:HendersonY CYC,
pubmed-author:HopeW GWG,
pubmed-author:LippmanS MSM,
pubmed-author:MerrittJ AJA,
pubmed-author:RothJ AJA,
pubmed-author:TimmonsT MTM,
pubmed-author:ZumsteinL ALA,
pubmed-author:el-NaggarA KAK
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2221-32
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:9626224-Adenoviridae,
pubmed-meshheading:9626224-Adult,
pubmed-meshheading:9626224-Aged,
pubmed-meshheading:9626224-Blotting, Southern,
pubmed-meshheading:9626224-Carcinoma, Squamous Cell,
pubmed-meshheading:9626224-DNA, Neoplasm,
pubmed-meshheading:9626224-Female,
pubmed-meshheading:9626224-Gene Transfer Techniques,
pubmed-meshheading:9626224-Genetic Vectors,
pubmed-meshheading:9626224-Head and Neck Neoplasms,
pubmed-meshheading:9626224-Humans,
pubmed-meshheading:9626224-Immunohistochemistry,
pubmed-meshheading:9626224-Injections, Intralesional,
pubmed-meshheading:9626224-Male,
pubmed-meshheading:9626224-Middle Aged,
pubmed-meshheading:9626224-Polymerase Chain Reaction,
pubmed-meshheading:9626224-Tomography, X-Ray Computed,
pubmed-meshheading:9626224-Treatment Outcome,
pubmed-meshheading:9626224-Tumor Suppressor Protein p53
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma.
|
|
pubmed:affiliation |
Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA. gclayman@notes.mdacc.tmc.edu
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I
|
