Linked Life Data

9625938

Source:http://linkedlifedata.com/resource/pubmed/id/9625938

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1998-7-10
pubmed:abstractText
Malaria can, a priori, kill on its own ('direct' malaria mortality) or in conjunction with some other cause(s) ('indirect' malaria mortality). There are three distinct approaches to the measurement of malaria mortality: (1) measurement of malaria-specific mortality (based on attributing each death to a single cause) or its surrogate, the admission rate for life-threatening malaria; (2) measurement of the reduction in all-cause mortality after removal (or near removal) of malaria; and (3) the estimation of the malaria mortality required to explain the observed frequency of the HbS gene. There is a strong indication that approaches (2) and (3) yield estimates of total (direct and indirect) malaria mortality which are at least twice as high as those obtained using approach (1), which probably measures mostly direct malaria mortality. There is currently a controversy about the long-term impact on mortality of reducing the intensity of malaria transmission from 'high' to 'intermediate', given the expected loss of immunity. Certain geographical comparisons (of the results of 'nature's experiment') indicate that, when the intensity of transmission is high, the incidence of life-threatening malaria falls. However, the seasonal variation in the intensity of transmission decreases with increases in the intensity; low seasonal variation is probably beneficial, allowing a smoother transition from passive to active immunity, but is unlikely to be reversed by preventive measures. It also seems likely that geographical comparisons produce estimates of predominantly direct mortality, which might not run in parallel with the indirect mortality. A tentative numerical exploration of the problem, using a simple demographic model, indicates that, if indirect malaria mortality is important and the other causes of death are concentrated in early life, the long-term impact on all-cause mortality of reducing exposure (although less than the short-term) will probably always be beneficial, even if there is some increase in direct malaria mortality.
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/Behavior, http://linkedlifedata.com/resource/pubmed/keyword/Causes Of Death, http://linkedlifedata.com/resource/pubmed/keyword/Demographic Factors, http://linkedlifedata.com/resource/pubmed/keyword/Diseases, http://linkedlifedata.com/resource/pubmed/keyword/EPIDEMIOLOGY, http://linkedlifedata.com/resource/pubmed/keyword/Health, http://linkedlifedata.com/resource/pubmed/keyword/Longterm Effects, http://linkedlifedata.com/resource/pubmed/keyword/Malaria--prevention and control, http://linkedlifedata.com/resource/pubmed/keyword/Mortality, http://linkedlifedata.com/resource/pubmed/keyword/PARASITIC DISEASES, http://linkedlifedata.com/resource/pubmed/keyword/PUBLIC HEALTH, http://linkedlifedata.com/resource/pubmed/keyword/Population, http://linkedlifedata.com/resource/pubmed/keyword/Population Dynamics, http://linkedlifedata.com/resource/pubmed/keyword/Risk Reduction Behavior, http://linkedlifedata.com/resource/pubmed/keyword/Time Factors, http://linkedlifedata.com/resource/pubmed/keyword/World
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0003-4983
pubmed:author
pubmed:issnType
Print
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
811-25
pubmed:dateRevised
2009-5-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Malaria and mortality: some epidemiological considerations.
pubmed:publicationType
Journal Article, Review