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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-8-20
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pubmed:abstractText |
Human papillomavirus (HPV) is the major cause of cervical cancer worldwide. HPV-E6 protein targets the p53 tumor suppressor protein for degradation by ubiquitin-mediated proteolysis making such cancers resistant to p53-gene therapy. Here we show that infection of human cancer cells by E6-expressing adenovirus (Ad-E6) leads to degradation of both wild-type or mutant p53 protein. Interestingly, the p53-homologue candidate tumor suppressor p73 is not degraded in Ad-E6 infected cancer cells. Wild-type p73beta and not wild-type p53 or mutant p73 is a potent inhibitor of cancer colony growth and inducer of apoptosis, despite HPV-E6 overexpression. The results suggest a novel strategy using p73beta in gene therapy of HPV-E6 expressing cancers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/E6 protein, Human papillomavirus...,
http://linkedlifedata.com/resource/pubmed/chemical/E6 protein, Human papillomavirus...,
http://linkedlifedata.com/resource/pubmed/chemical/Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/tumor suppressor protein p73
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1019-6439
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9625796-Apoptosis,
pubmed-meshheading:9625796-DNA-Binding Proteins,
pubmed-meshheading:9625796-Genes, Tumor Suppressor,
pubmed-meshheading:9625796-Humans,
pubmed-meshheading:9625796-Ligases,
pubmed-meshheading:9625796-Nuclear Proteins,
pubmed-meshheading:9625796-Oncogene Proteins, Viral,
pubmed-meshheading:9625796-Papillomaviridae,
pubmed-meshheading:9625796-Papillomavirus Infections,
pubmed-meshheading:9625796-Protein Binding,
pubmed-meshheading:9625796-Repressor Proteins,
pubmed-meshheading:9625796-Tumor Cells, Cultured,
pubmed-meshheading:9625796-Tumor Suppressor Protein p53,
pubmed-meshheading:9625796-Tumor Suppressor Proteins,
pubmed-meshheading:9625796-Tumor Virus Infections,
pubmed-meshheading:9625796-Ubiquitin-Protein Ligases
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pubmed:year |
1998
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pubmed:articleTitle |
p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells.
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pubmed:affiliation |
Laboratory of Molecular Oncology and Cell Cycle Regulation, Howard Hughes Medical Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6148, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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