Linked Life Data

9625267

Source:http://linkedlifedata.com/resource/pubmed/id/9625267

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-8-12
pubmed:abstractText
The pharmacokinetics of pravastatin, a serum-cholesterol-lowering drug, were studied in 20 middle-aged (46-59 years old, n = 8) and elderly subjects (60-81 years old, n = 12). Pravastatin serum levels were determined by HPLC and solid phase extraction. Cmax was 48.9 +/- 7.1 ng/ml (mean +/- SEM, n = 20), and the mean AUC0-4.5h was 104.4 ng x h/ml (n = 5) for a 20 mg daily oral dose. A great interindividual variability was found for Cmax, which varied from 6.2 ng/ml to 117.8 ng/ml on the 20 mg dose. As could be expected, Cmax and AUC0-4.5h were dose-related, but Tmax and t1/2 were not. In six cases, the elimination of the drug in serum could be described by a single phase but in four cases with two phases. No significant difference was found in Cmax between the middle-aged and the elderly or between males and females.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0378-7966
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-8
pubmed:dateRevised
2011-2-2
pubmed:meshHeading
pubmed:articleTitle
A pharmacokinetic evaluation of pravastatin in middle-aged and elderly volunteers.
pubmed:affiliation
Department of Pharmacology, University of Iceland, Reykjavik.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't