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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1998-7-7
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pubmed:abstractText |
We are presently investigating the therapeutic potential of herpes simplex-thymidine kinase-expressing donor T cells in the setting of a T cell-depleted allogeneic bone marrow transplantation. The generation, expansion, and selection of the gene-modified T cells require a 12-day ex vivo culture period in high-dose interleukin (IL)-2 that could significantly alter their in vivo alloreactivity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1365-70
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9625020-Acute Disease,
pubmed-meshheading:9625020-Animals,
pubmed-meshheading:9625020-Bone Marrow Transplantation,
pubmed-meshheading:9625020-Cell Transplantation,
pubmed-meshheading:9625020-Gene Transfer Techniques,
pubmed-meshheading:9625020-Graft vs Host Disease,
pubmed-meshheading:9625020-Herpes Simplex,
pubmed-meshheading:9625020-Interleukin-2,
pubmed-meshheading:9625020-Lymphocyte Depletion,
pubmed-meshheading:9625020-Male,
pubmed-meshheading:9625020-Mice,
pubmed-meshheading:9625020-Mice, Inbred BALB C,
pubmed-meshheading:9625020-Mice, Inbred C57BL,
pubmed-meshheading:9625020-T-Lymphocytes,
pubmed-meshheading:9625020-Thymidine Kinase,
pubmed-meshheading:9625020-Time Factors,
pubmed-meshheading:9625020-Tissue Donors,
pubmed-meshheading:9625020-Transplantation, Homologous
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pubmed:year |
1998
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pubmed:articleTitle |
In vivo alloreactive potential of ex vivo-expanded primary T lymphocytes.
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pubmed:affiliation |
Laboratoire de Thérapeutique Immuno-moléculaire, Etablissement de Transfusion Sanguine de Franche-Comté, Besançon, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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