| pubmed-article:9623977 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9623977 | lifeskim:mentions | umls-concept:C1506928 | lld:lifeskim |
| pubmed-article:9623977 | lifeskim:mentions | umls-concept:C1705438 | lld:lifeskim |
| pubmed-article:9623977 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:9623977 | lifeskim:mentions | umls-concept:C0017638 | lld:lifeskim |
| pubmed-article:9623977 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:9623977 | lifeskim:mentions | umls-concept:C0598934 | lld:lifeskim |
| pubmed-article:9623977 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:9623977 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:9623977 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:9623977 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:9623977 | pubmed:dateCreated | 1998-6-26 | lld:pubmed |
| pubmed-article:9623977 | pubmed:abstractText | The transfer of apoptosis genes to tumors is one of the most promising strategies for cancer gene therapy. We have shown that massive apoptosis occurs when wild-type p53 expression is induced in glioma cells carrying a p53 gene mutation. However, adenovirus-mediated p53 gene transfer is ineffective in causing apoptosis in glioma cells that retain a wild-type p53 genotype. We evaluated the effect of E2F-1 overexpression on the growth of gliomas in vitro and in vivo. In the in vitro study, the adenovirus-mediated transfer of exogenous E2F-1 protein precipitated generalized apoptosis in gliomas. The treatment with Ad5CMV-E2F-1 of nude mice carrying subcutaneous gliomas arrested tumor growth. Our results indicate that E2F-1 has anti-glioma activity in vitro and in vivo. | lld:pubmed |
| pubmed-article:9623977 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9623977 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9623977 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9623977 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9623977 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:9623977 | pubmed:author | pubmed-author:LevinV AVA | lld:pubmed |
| pubmed-article:9623977 | pubmed:author | pubmed-author:YungW KWK | lld:pubmed |
| pubmed-article:9623977 | pubmed:author | pubmed-author:RayJ MJM | lld:pubmed |
| pubmed-article:9623977 | pubmed:author | pubmed-author:DAWH THT | lld:pubmed |
| pubmed-article:9623977 | pubmed:author | pubmed-author:ShiXX | lld:pubmed |
| pubmed-article:9623977 | pubmed:author | pubmed-author:FueyoJJ | lld:pubmed |
| pubmed-article:9623977 | pubmed:author | pubmed-author:KyritsisA PAP | lld:pubmed |
| pubmed-article:9623977 | pubmed:author | pubmed-author:McDonnellT... | lld:pubmed |
| pubmed-article:9623977 | pubmed:author | pubmed-author:AlemanyRR | lld:pubmed |
| pubmed-article:9623977 | pubmed:author | pubmed-author:Gomez-Manzano... | lld:pubmed |
| pubmed-article:9623977 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9623977 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:9623977 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9623977 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9623977 | pubmed:pagination | 685-90 | lld:pubmed |
| pubmed-article:9623977 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9623977 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9623977 | pubmed:articleTitle | Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo. | lld:pubmed |
| pubmed-article:9623977 | pubmed:affiliation | Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA. | lld:pubmed |
| pubmed-article:9623977 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9623977 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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