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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-6-26
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pubmed:abstractText |
The transfer of apoptosis genes to tumors is one of the most promising strategies for cancer gene therapy. We have shown that massive apoptosis occurs when wild-type p53 expression is induced in glioma cells carrying a p53 gene mutation. However, adenovirus-mediated p53 gene transfer is ineffective in causing apoptosis in glioma cells that retain a wild-type p53 genotype. We evaluated the effect of E2F-1 overexpression on the growth of gliomas in vitro and in vivo. In the in vitro study, the adenovirus-mediated transfer of exogenous E2F-1 protein precipitated generalized apoptosis in gliomas. The treatment with Ad5CMV-E2F-1 of nude mice carrying subcutaneous gliomas arrested tumor growth. Our results indicate that E2F-1 has anti-glioma activity in vitro and in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arid4a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/E2F Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/E2F1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/E2F1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/E2f1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Protein p21(ras),
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma-Binding Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor DP1,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1078-8956
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
685-90
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9623977-Adenoviruses, Human,
pubmed-meshheading:9623977-Animals,
pubmed-meshheading:9623977-Apoptosis,
pubmed-meshheading:9623977-Carrier Proteins,
pubmed-meshheading:9623977-Cell Cycle Proteins,
pubmed-meshheading:9623977-Cell Death,
pubmed-meshheading:9623977-Cell Survival,
pubmed-meshheading:9623977-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:9623977-DNA-Binding Proteins,
pubmed-meshheading:9623977-Disease Models, Animal,
pubmed-meshheading:9623977-E2F Transcription Factors,
pubmed-meshheading:9623977-E2F1 Transcription Factor,
pubmed-meshheading:9623977-Gene Expression,
pubmed-meshheading:9623977-Gene Therapy,
pubmed-meshheading:9623977-Genes, Tumor Suppressor,
pubmed-meshheading:9623977-Genetic Vectors,
pubmed-meshheading:9623977-Glioma,
pubmed-meshheading:9623977-Humans,
pubmed-meshheading:9623977-Mice,
pubmed-meshheading:9623977-Mice, Inbred BALB C,
pubmed-meshheading:9623977-Mice, Nude,
pubmed-meshheading:9623977-Oncogene Protein p21(ras),
pubmed-meshheading:9623977-Recombinant Fusion Proteins,
pubmed-meshheading:9623977-Retinoblastoma Protein,
pubmed-meshheading:9623977-Retinoblastoma-Binding Protein 1,
pubmed-meshheading:9623977-Transcription Factor DP1,
pubmed-meshheading:9623977-Transcription Factors,
pubmed-meshheading:9623977-Transfection,
pubmed-meshheading:9623977-Tumor Cells, Cultured
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pubmed:year |
1998
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pubmed:articleTitle |
Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo.
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pubmed:affiliation |
Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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