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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1998-8-5
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pubmed:abstractText |
Effects of nitric oxide (NO) synthase inhibitors on the enoxacin-induced convulsions were examined in mice pretreated with fenbufen. 7-nitroindazole markedly suppressed the incidence of convulsions, whereas L-arginine did not modify the convulsions at all. The suppression of the convulsions by 7-nitroindazole was not reversed by the pretreatment of L-arginine. Brain NO synthase activity was significantly raised at 30 min after enoxacin when combined with fenbufen. The increased NO synthase activity was found to be suppressed by the pretreatment of 7-nitroindazole. These findings suggest that endogenous NO may be involved as a proconvulsant substance in the development of enoxacin-induced convulsions in mice pretreated with fenbufen.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/7-nitroindazole,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Infective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Enoxacin,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Indazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Nos1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylbutyrates,
http://linkedlifedata.com/resource/pubmed/chemical/fenbufen
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0021-5198
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
425-9
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9623721-Animals,
pubmed-meshheading:9623721-Anti-Infective Agents,
pubmed-meshheading:9623721-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:9623721-Brain,
pubmed-meshheading:9623721-Enoxacin,
pubmed-meshheading:9623721-Enzyme Inhibitors,
pubmed-meshheading:9623721-Indazoles,
pubmed-meshheading:9623721-Male,
pubmed-meshheading:9623721-Mice,
pubmed-meshheading:9623721-Nitric Oxide,
pubmed-meshheading:9623721-Nitric Oxide Synthase,
pubmed-meshheading:9623721-Nitric Oxide Synthase Type I,
pubmed-meshheading:9623721-Phenylbutyrates,
pubmed-meshheading:9623721-Seizures
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pubmed:year |
1998
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pubmed:articleTitle |
Role of nitric oxide in the convulsions following the coadministration of enoxacin with fenbufen in mice.
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pubmed:affiliation |
Department of Clinical Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan.
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pubmed:publicationType |
Journal Article
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