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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-8-14
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pubmed:abstractText |
In the presence of low serum folate, mutant 5,20-methylenetetrahydrofolate reductase (MTHFR + [A223V/C677T]) in the homozygous state (+/+), may predispose to higher plasma homocysteine (tHct) levels and coronary artery disease (CAD). To determine the impact of this relationship on predisposition to early-onset CAD, we examined the prevalence of the mutation and plasma tHct in patients with early-onset CAD and compared them to patients manifesting CAD later in life.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-9120
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
95-100
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pubmed:dateRevised |
2009-11-3
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pubmed:meshHeading |
pubmed-meshheading:9622772-Age of Onset,
pubmed-meshheading:9622772-Aged,
pubmed-meshheading:9622772-Autoanalysis,
pubmed-meshheading:9622772-Chromatography, High Pressure Liquid,
pubmed-meshheading:9622772-Coronary Disease,
pubmed-meshheading:9622772-Disease Susceptibility,
pubmed-meshheading:9622772-Genetic Variation,
pubmed-meshheading:9622772-Genotype,
pubmed-meshheading:9622772-Heterozygote,
pubmed-meshheading:9622772-Homocysteine,
pubmed-meshheading:9622772-Homozygote,
pubmed-meshheading:9622772-Humans,
pubmed-meshheading:9622772-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:9622772-Middle Aged,
pubmed-meshheading:9622772-Oxidoreductases Acting on CH-NH Group Donors,
pubmed-meshheading:9622772-Point Mutation
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pubmed:year |
1998
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pubmed:articleTitle |
Relation of a common mutation in methylenetetrahydrofolate reductase to plasma homocysteine and early onset coronary artery disease.
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pubmed:affiliation |
Department of Pathology, Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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