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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
|
pubmed:dateCreated |
1998-8-19
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pubmed:abstractText |
Accumulating evidence indicates that the mechanism for causing AIDS dementia complex (ADC) involves the release of damaging inflammatory-related agents by HIV-infected microglia in the brain resulting in CNS oxidative damage. One such agent, tumor necrosis factor alpha (TNF-alpha) is consistently elevated in the brains of ADC patients compared to non-demented HIV patients. To model this aspect of ADC in rats, chronic ventricular infusions of TNF-alpha were given and found to induce several aspects of ADC, including weight loss, learning/memory impairment, enlarged lateral ventricles, and increased apoptosis. Concurrent oral treatment with the antioxidant CPI-1189 prevented all of these TNF-alpha induced effects. The results support TNF-alpha as a key toxic agent in ADC and provide the first in vivo evidence that chronic treatment with a synthetic antioxidant may protect HIV-infected patients against ADC. Our findings may also have implications in other neurological diseases where brain TNF-alpha levels are elevated and inflammation/oxidative stress is suspected to be a contributing cause, such as Alzheimer's disease and Parkinson's disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
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pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 1998 Elsevier Science B.V. All rights reserved.
|
pubmed:issnType |
Print
|
pubmed:day |
8
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pubmed:volume |
795
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
349-57
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9622673-AIDS Dementia Complex,
pubmed-meshheading:9622673-Animals,
pubmed-meshheading:9622673-Antioxidants,
pubmed-meshheading:9622673-Apoptosis,
pubmed-meshheading:9622673-Behavior, Animal,
pubmed-meshheading:9622673-Body Weight,
pubmed-meshheading:9622673-Cognition,
pubmed-meshheading:9622673-Disease Models, Animal,
pubmed-meshheading:9622673-Male,
pubmed-meshheading:9622673-Memory,
pubmed-meshheading:9622673-Neuroprotective Agents,
pubmed-meshheading:9622673-Rats,
pubmed-meshheading:9622673-Rats, Sprague-Dawley,
pubmed-meshheading:9622673-Tumor Necrosis Factor-alpha
|
pubmed:year |
1998
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pubmed:articleTitle |
Preventive actions of a synthetic antioxidant in a novel animal model of AIDS dementia.
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pubmed:affiliation |
Dept. of Psychology, University of South Florida, Tampa, FL 33620, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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