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rdf:type |
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lifeskim:mentions |
umls-concept:C0006684,
umls-concept:C0026336,
umls-concept:C0026339,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0443199,
umls-concept:C0494491,
umls-concept:C1153440,
umls-concept:C1280500,
umls-concept:C1517004,
umls-concept:C1521801
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pubmed:issue |
2
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pubmed:dateCreated |
1998-8-27
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pubmed:abstractText |
We investigated the effects of intrathecally administered N-type and P-type voltage-sensitive calcium channel (VSCC) blockers on the level of thermal hyperalgesia in two neuropathic pain models: the chronic constriction injury (CCI) model and the partial sciatic nerve injury (PSNI) model. N-type, but not P-type, VSCC blockers attenuated the level of thermal hyperalgesia induced by CCI in a dose-dependent manner. In the PSNI model, both N-type and P-type VSCC blockers had no effect on thermal hyperalgesia. This suggests that some types of neuropathic pain may be treatable with N-type VSCC blockers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1998 Elsevier Science B.V. All rights reserved.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
794
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
329-32
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9622667-Analysis of Variance,
pubmed-meshheading:9622667-Animals,
pubmed-meshheading:9622667-Calcium Channel Blockers,
pubmed-meshheading:9622667-Constriction,
pubmed-meshheading:9622667-Disease Models, Animal,
pubmed-meshheading:9622667-Injections, Spinal,
pubmed-meshheading:9622667-Male,
pubmed-meshheading:9622667-Membrane Potentials,
pubmed-meshheading:9622667-Neuralgia,
pubmed-meshheading:9622667-Neuroprotective Agents,
pubmed-meshheading:9622667-Peptides,
pubmed-meshheading:9622667-Rats,
pubmed-meshheading:9622667-Rats, Sprague-Dawley,
pubmed-meshheading:9622667-Sciatic Nerve,
pubmed-meshheading:9622667-Spider Venoms,
pubmed-meshheading:9622667-omega-Agatoxin IVA,
pubmed-meshheading:9622667-omega-Conotoxin GVIA,
pubmed-meshheading:9622667-omega-Conotoxins
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pubmed:year |
1998
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pubmed:articleTitle |
Differential effects of intrathecally administered N- and P-type voltage-sensitive calcium channel blockers upon two models of experimental mononeuropathy in the rat.
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pubmed:affiliation |
Department of Anesthesiology, School of Medicine, Chiba University, Chiba 260-0856, Japan. yamatat@med.m.chiba-u.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study
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