| pubmed-article:9621915 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9621915 | lifeskim:mentions | umls-concept:C0175677 | lld:lifeskim |
| pubmed-article:9621915 | lifeskim:mentions | umls-concept:C0178795 | lld:lifeskim |
| pubmed-article:9621915 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:9621915 | lifeskim:mentions | umls-concept:C0043047 | lld:lifeskim |
| pubmed-article:9621915 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:9621915 | lifeskim:mentions | umls-concept:C0228174 | lld:lifeskim |
| pubmed-article:9621915 | lifeskim:mentions | umls-concept:C0442043 | lld:lifeskim |
| pubmed-article:9621915 | lifeskim:mentions | umls-concept:C0014272 | lld:lifeskim |
| pubmed-article:9621915 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:9621915 | lifeskim:mentions | umls-concept:C0012222 | lld:lifeskim |
| pubmed-article:9621915 | lifeskim:mentions | umls-concept:C1707429 | lld:lifeskim |
| pubmed-article:9621915 | lifeskim:mentions | umls-concept:C0220784 | lld:lifeskim |
| pubmed-article:9621915 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:9621915 | pubmed:dateCreated | 1998-8-21 | lld:pubmed |
| pubmed-article:9621915 | pubmed:abstractText | Cerebral apparent diffusion coefficients (ADCs) were determined in nine newborn piglets before and for 48 h after transient hypoxia-ischemia. Phosphorus MRS revealed severely reduced cerebral energy metabolism during the insult and an apparently complete recovery 2 h after resuscitation commenced. At this time, mean ADC over the imaging slice (ADCglobal) was 0.88 (0.04) x 10(-9) m2 x s(-1) (mean (SD)), which was close to the baseline value of 0.92 (0.4) x 10(-9) m2 x s(-1). In seven of the animals, a "secondary" failure of energy metabolism then evolved, accompanied by a decline in ADCglobal to 0.64 (0.17) x 10(-9) m2 x s(-1) at 46 h postresuscitation (P < 0.001 versus baseline). For these seven animals, ADCglobal correlated linearly with the concentration ratio [phosphocreatine (PCr)]/[inorganic phosphate (Pi)] (0.94 < r < 0.99; P < 0.001). A nonlinear relationship was demonstrated between ADCglobal and the concentration ratio [nucleotide triphosphate (NTP)]/[Pi + PCr + 3 NTP]. The ADC reduction commenced in the parasagittal cortex before spreading in a characteristic pattern throughout the brain. ADC seems to be closely related to cerebral energy status and shows considerable potential for the assessment of hypoxic-ischemic injury in the newborn brain. | lld:pubmed |
| pubmed-article:9621915 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9621915 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9621915 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9621915 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9621915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9621915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9621915 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9621915 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9621915 | pubmed:issn | 0740-3194 | lld:pubmed |
| pubmed-article:9621915 | pubmed:author | pubmed-author:ThorntonJ SJS | lld:pubmed |
| pubmed-article:9621915 | pubmed:author | pubmed-author:WyattJ SJS | lld:pubmed |
| pubmed-article:9621915 | pubmed:author | pubmed-author:OrdidgeR JRJ | lld:pubmed |
| pubmed-article:9621915 | pubmed:author | pubmed-author:CadyE BEB | lld:pubmed |
| pubmed-article:9621915 | pubmed:author | pubmed-author:PenriceJJ | lld:pubmed |
| pubmed-article:9621915 | pubmed:author | pubmed-author:ClemenceMM | lld:pubmed |
| pubmed-article:9621915 | pubmed:author | pubmed-author:AmessP NPN | lld:pubmed |
| pubmed-article:9621915 | pubmed:author | pubmed-author:PunwaniSS | lld:pubmed |
| pubmed-article:9621915 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9621915 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:9621915 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9621915 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9621915 | pubmed:pagination | 920-7 | lld:pubmed |
| pubmed-article:9621915 | pubmed:dateRevised | 2009-9-29 | lld:pubmed |
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| pubmed-article:9621915 | pubmed:meshHeading | pubmed-meshheading:9621915-... | lld:pubmed |
| pubmed-article:9621915 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9621915 | pubmed:articleTitle | Temporal and anatomical variations of brain water apparent diffusion coefficient in perinatal cerebral hypoxic-ischemic injury: relationships to cerebral energy metabolism. | lld:pubmed |
| pubmed-article:9621915 | pubmed:affiliation | Department of Medical Physics, University College London, United Kingdom. | lld:pubmed |
| pubmed-article:9621915 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9621915 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
