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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1998-8-21
|
| pubmed:abstractText |
Cerebral apparent diffusion coefficients (ADCs) were determined in nine newborn piglets before and for 48 h after transient hypoxia-ischemia. Phosphorus MRS revealed severely reduced cerebral energy metabolism during the insult and an apparently complete recovery 2 h after resuscitation commenced. At this time, mean ADC over the imaging slice (ADCglobal) was 0.88 (0.04) x 10(-9) m2 x s(-1) (mean (SD)), which was close to the baseline value of 0.92 (0.4) x 10(-9) m2 x s(-1). In seven of the animals, a "secondary" failure of energy metabolism then evolved, accompanied by a decline in ADCglobal to 0.64 (0.17) x 10(-9) m2 x s(-1) at 46 h postresuscitation (P < 0.001 versus baseline). For these seven animals, ADCglobal correlated linearly with the concentration ratio [phosphocreatine (PCr)]/[inorganic phosphate (Pi)] (0.94 < r < 0.99; P < 0.001). A nonlinear relationship was demonstrated between ADCglobal and the concentration ratio [nucleotide triphosphate (NTP)]/[Pi + PCr + 3 NTP]. The ADC reduction commenced in the parasagittal cortex before spreading in a characteristic pattern throughout the brain. ADC seems to be closely related to cerebral energy status and shows considerable potential for the assessment of hypoxic-ischemic injury in the newborn brain.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0740-3194
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
39
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
920-7
|
| pubmed:dateRevised |
2009-9-29
|
| pubmed:meshHeading |
pubmed-meshheading:9621915-Animals,
pubmed-meshheading:9621915-Animals, Newborn,
pubmed-meshheading:9621915-Asphyxia Neonatorum,
pubmed-meshheading:9621915-Blood-Brain Barrier,
pubmed-meshheading:9621915-Body Water,
pubmed-meshheading:9621915-Brain,
pubmed-meshheading:9621915-Brain Damage, Chronic,
pubmed-meshheading:9621915-Brain Edema,
pubmed-meshheading:9621915-Diffusion,
pubmed-meshheading:9621915-Humans,
pubmed-meshheading:9621915-Hypoxia, Brain,
pubmed-meshheading:9621915-Image Processing, Computer-Assisted,
pubmed-meshheading:9621915-Infant, Newborn,
pubmed-meshheading:9621915-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9621915-Phantoms, Imaging,
pubmed-meshheading:9621915-Phosphates,
pubmed-meshheading:9621915-Phosphocreatine,
pubmed-meshheading:9621915-Swine
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Temporal and anatomical variations of brain water apparent diffusion coefficient in perinatal cerebral hypoxic-ischemic injury: relationships to cerebral energy metabolism.
|
| pubmed:affiliation |
Department of Medical Physics, University College London, United Kingdom.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|