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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1998-7-1
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pubmed:abstractText |
Polymorphisms in the coding sequences of CCR5 and CXCR4 were studied in a group of human immunodeficiency virus (HIV)-infected long-term nonprogressors. Two different point mutations were found in the CXCR4 coding sequence. One of these CXCR4 mutations was silent, and each was unique to two nonprogressors. The well-described 32-bp deletion within the CCR5 coding sequence (CCR5-Delta32) was found in 4 of 13 nonprogressors, and 12 different point mutations were found scattered over the CCR5 coding sequence from 8 nonprogressors. Most of the mutations created either silent or conservative changes in the predicted amino acid sequence: only one of these mutations was found in more than a single nonprogressor. All nonsilent mutations were tested in an HIV envelope-dependent fusion assay, and all functioned comparably to wild-type controls. Polymorphisms in the CXCR4 and CCR5 coding sequences other than CCR5-Delta32 do not appear to play a dominant mechanistic role in nonprogression among HIV-infected individuals.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-8276799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-8629022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-8639485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-8649511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-8649512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-8658171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-8674119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-8674120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-8751444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-8756719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-8791590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-8898752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-9050881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-9055842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-9055864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-9130946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-9132277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-9147421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-9151905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-9207783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-9294127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-9371631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-9416501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-9430590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9621092-9500612
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6215-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9621092-Female,
pubmed-meshheading:9621092-HIV Infections,
pubmed-meshheading:9621092-Humans,
pubmed-meshheading:9621092-Male,
pubmed-meshheading:9621092-Mutation,
pubmed-meshheading:9621092-Polymorphism, Genetic,
pubmed-meshheading:9621092-Receptors, CCR5,
pubmed-meshheading:9621092-Receptors, CXCR4
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pubmed:year |
1998
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pubmed:articleTitle |
CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection: lack of association with mutations other than CCR5-Delta32.
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pubmed:affiliation |
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-1876, USA. OCohen@nih.gov
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pubmed:publicationType |
Journal Article
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