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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1998-6-18
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pubmed:abstractText |
Acute, low-doses of ultraviolet (UV)-B radiation affect the immune competent cells of the skin immune system. In this study, we examined the time-dependent changes of the cutaneous T cell population in normal human volunteers following a single local exposure to UV. Solar-simulated UV radiation caused an initial decrease in intraepidermal T cell numbers, even leading to T cell depletion at day 4, whereupon a considerable infiltration of T cells in the epidermis occurred that peaked at day 14. In the dermis the number of T cells was markedly increased at days 2 (peak) and 4 after irradiation, and subsequently declined to the nonirradiated control values at day 10. Double-staining with several T cell markers showed that the T cells, infiltrating the (epi)dermis upon UV exposure, were almost exclusively CD4+ CD45RO+ T cells, expressing an alpha/beta type T cell receptor, but lacking the activation markers HLA-DR, VLA-1, and IL-2R. Application of UVB radiation resulted in similar dynamics of T cells, indicating that the UVB wavelengths within the solar-simulated UV radiation were responsible for the selective influx of CD4+ T cells. In conjunction with UVB-induced alterations in the type and function of antigen-presenting cells (i.e., Langerhans cells and macrophages), the changes of the cutaneous T cell population may also contribute to UVB-induced immunosuppression at skin level in man.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
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pubmed:issn |
0022-202X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
110
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
978-81
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9620309-Adolescent,
pubmed-meshheading:9620309-Adult,
pubmed-meshheading:9620309-Antigens, CD3,
pubmed-meshheading:9620309-Antigens, CD4,
pubmed-meshheading:9620309-Antigens, CD8,
pubmed-meshheading:9620309-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9620309-Dose-Response Relationship, Radiation,
pubmed-meshheading:9620309-Female,
pubmed-meshheading:9620309-Humans,
pubmed-meshheading:9620309-Immunologic Memory,
pubmed-meshheading:9620309-Male,
pubmed-meshheading:9620309-Middle Aged,
pubmed-meshheading:9620309-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:9620309-Skin,
pubmed-meshheading:9620309-Sunlight,
pubmed-meshheading:9620309-T-Lymphocyte Subsets,
pubmed-meshheading:9620309-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:9620309-Time Factors,
pubmed-meshheading:9620309-Ultraviolet Rays
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pubmed:year |
1998
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pubmed:articleTitle |
UVB radiation preferentially induces recruitment of memory CD4+ T cells in normal human skin: long-term effect after a single exposure.
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pubmed:affiliation |
Department of Dermatology, Academic Medical Center, University of Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|