Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-6-18
pubmed:abstractText
Acute, low-doses of ultraviolet (UV)-B radiation affect the immune competent cells of the skin immune system. In this study, we examined the time-dependent changes of the cutaneous T cell population in normal human volunteers following a single local exposure to UV. Solar-simulated UV radiation caused an initial decrease in intraepidermal T cell numbers, even leading to T cell depletion at day 4, whereupon a considerable infiltration of T cells in the epidermis occurred that peaked at day 14. In the dermis the number of T cells was markedly increased at days 2 (peak) and 4 after irradiation, and subsequently declined to the nonirradiated control values at day 10. Double-staining with several T cell markers showed that the T cells, infiltrating the (epi)dermis upon UV exposure, were almost exclusively CD4+ CD45RO+ T cells, expressing an alpha/beta type T cell receptor, but lacking the activation markers HLA-DR, VLA-1, and IL-2R. Application of UVB radiation resulted in similar dynamics of T cells, indicating that the UVB wavelengths within the solar-simulated UV radiation were responsible for the selective influx of CD4+ T cells. In conjunction with UVB-induced alterations in the type and function of antigen-presenting cells (i.e., Langerhans cells and macrophages), the changes of the cutaneous T cell population may also contribute to UVB-induced immunosuppression at skin level in man.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-202X
pubmed:author
pubmed:issnType
Print
pubmed:volume
110
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
978-81
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:9620309-Adolescent, pubmed-meshheading:9620309-Adult, pubmed-meshheading:9620309-Antigens, CD3, pubmed-meshheading:9620309-Antigens, CD4, pubmed-meshheading:9620309-Antigens, CD8, pubmed-meshheading:9620309-CD4-Positive T-Lymphocytes, pubmed-meshheading:9620309-Dose-Response Relationship, Radiation, pubmed-meshheading:9620309-Female, pubmed-meshheading:9620309-Humans, pubmed-meshheading:9620309-Immunologic Memory, pubmed-meshheading:9620309-Male, pubmed-meshheading:9620309-Middle Aged, pubmed-meshheading:9620309-Receptors, Antigen, T-Cell, alpha-beta, pubmed-meshheading:9620309-Skin, pubmed-meshheading:9620309-Sunlight, pubmed-meshheading:9620309-T-Lymphocyte Subsets, pubmed-meshheading:9620309-T-Lymphocytes, Helper-Inducer, pubmed-meshheading:9620309-Time Factors, pubmed-meshheading:9620309-Ultraviolet Rays
pubmed:year
1998
pubmed:articleTitle
UVB radiation preferentially induces recruitment of memory CD4+ T cells in normal human skin: long-term effect after a single exposure.
pubmed:affiliation
Department of Dermatology, Academic Medical Center, University of Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial