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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-7-17
|
| pubmed:abstractText |
In vitro, cytosolic human ketone reductases catalyse the stereospecific (i.e. >99%) formation of S(-) reduced haloperidol (RHP) from haloperidol (HP). Whether this situation is reflected in patients taking the drug is unknown. In this study in nine patients taking HP, only 73.2+/-18.2% of the RHP excreted in urine was the S(-) enantiomer. Thus, enzymes other than cytosolic ketone reductases must be responsible for the formation of the minor enantiomer.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0924-977X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
127-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9619691-Adult,
pubmed-meshheading:9619691-Antipsychotic Agents,
pubmed-meshheading:9619691-Chromatography, High Pressure Liquid,
pubmed-meshheading:9619691-Haloperidol,
pubmed-meshheading:9619691-Humans,
pubmed-meshheading:9619691-Male,
pubmed-meshheading:9619691-Middle Aged,
pubmed-meshheading:9619691-Oxidation-Reduction,
pubmed-meshheading:9619691-Stereoisomerism
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Chirality of reduced haloperidol in humans.
|
| pubmed:affiliation |
Queensland Centre for Schizophrenia Research, Wolston Park Hospital, Wacol, Brisbane, Australia.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|