Linked Life Data

9619612

Source:http://linkedlifedata.com/resource/pubmed/id/9619612

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1998-7-28
pubmed:abstractText
We hypothesized, on the basis of in vitro observations, that a higher oxygen partial pressure within perfluorocarbon-containing microbubbles (PCMB) would enhance inward nitrogen diffusion after venous injection, leading to improved myocardial contrast. The in vitro studies measured PCMB size and concentration after injection into arterial blood that was obtained during inhalation of either room air or 100% oxygen. We then compared the myocardial contrast produced from PCMB sonicated in the presence of either a nitrogen-free environment (100% oxygen) or room air in three closed chest dogs. PCMB exposed to oxygenated blood in vitro were significantly smaller after insonation than PCMB exposed to arterial blood obtained during room air inhalation, confirming the important role of dissolved nitrogen in stabilizing PCMB size. In vivo studies demonstrated that intravenous PCMB sonicated with 100% oxygen produced significantly greater anterior and posterior myocardial contrast than PCMB sonicated in the presence of room air.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0894-7317
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
421-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Effect of blood and microbubble oxygen and nitrogen content on perfluorocarbon-filled dextrose albumin microbubble size and efficacy: in vitro and in vivo studies.
pubmed:affiliation
University of Nebraska Medical Center, Omaha 68198-1165, USA.
pubmed:publicationType
Journal Article, In Vitro