Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1998-7-9
pubmed:databankReference
pubmed:abstractText
Enhanced long chain fatty acid synthesis may occur in breast cancer, where it is necessary for tumor growth and predicts a poor prognosis. "Spot 14" (S14) is a carbohydrate- and thyroid hormone-inducible nuclear protein specific to liver, adipose, and lactating mammary tissues that functions to activate genes encoding the enzymes of fatty acid synthesis. Amplification of chromosome region 11q13, where the S14 gene (THRSP) resides, also predicts a poor prognosis in breast tumors. We localized the S14 gene between markers D11S906 and D11S937, at the telomeric end of the amplified region at 11q13, and found that it was amplified and expressed in breast cancer-derived cell lines. Moreover, concordant expression of S14 and a key lipogenic enzyme (acetyl-CoA carboxylase) in a panel of primary breast cancer specimens strongly supported a role for S14 as a determinant of tumor lipid metabolism. S14 expression provides a pathophysiological link between two prognostic indicators in breast cancer: enhanced lipogenesis and 11q13 amplification.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-1315716, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-1349162, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-1384661, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-1394126, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-1446647, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-1461654, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-1525062, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-1568216, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-2078507, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-2475778, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-2584193, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-3319781, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-3760185, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-4065033, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-6199351, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-6334237, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-6366794, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-7507699, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-7535085, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-7607576, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-7622469, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-7698220, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-7749140, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-7835891, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-7898937, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8022773, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8088842, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8102096, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8134364, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8168995, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8208295, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8336939, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8378318, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8474448, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8630954, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8640795, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8665507, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8780752, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8816886, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8893820, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8945620, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-8999918, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-9003802, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-9065811, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-9070914, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-9070921, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-9119371, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-9186528, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-9191002, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-9284908, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-9325252, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-9371405, http://linkedlifedata.com/resource/pubmed/commentcorrection/9618526-9389499
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6989-94
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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