Linked Life Data

9616801

Source:http://linkedlifedata.com/resource/pubmed/id/9616801

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1998-6-24
pubmed:abstractText
Alterations in serotonin neurotransmission have been implicated in the pathophysiology of major depression and suicide. However, a clear picture of serotonergic abnormalities has not emerged from postmortem studies of depression and suicide. In suicide victims with major depression and psychiatrically normal control subjects, we have examined various indices of serotonergic neurotransmission in axonal projection areas such as prefrontal cortex and hippocampus, and cell bodies of origin within the dorsal raphe nucleus (DR). Although there were no significant differences between suicide victims with major depression and psychiatrically normal control subjects in serotonin-1A or serotonin-2A receptors in the right prefrontal cortex (area 10) or the hippocampus, there were region-specific alterations in suicide victims with major depression in G-protein-induced activation of the phosphoinositide signal transduction system and in the levels of G-protein alpha subunits involved in cyclic AMP synthesis. A pilot study examining the ventrolateral subnucleus of the DR (DRvl) reveals that serotonin-1A receptors are increased in suicide victims with major depression as compared to normal control subjects. Altered signal transduction in cerebral cortex and altered regulation of serotonin neurons in the DR may be important in the pathophysiology of major depression and suicide.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
836
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
220-32
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Neurobiology of serotonin in depression and suicide.
pubmed:affiliation
Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106-5078, USA. cas9@po.cwru.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't