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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5369
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pubmed:dateCreated |
1998-6-22
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pubmed:databankReference |
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pubmed:abstractText |
A human member of the immunoglobulin superfamily was shown to mediate entry of several alphaherpesviruses, including herpes simplex viruses (HSV) 1 and 2, porcine pseudorabies virus (PRV), and bovine herpesvirus 1 (BHV-1). This membrane glycoprotein is poliovirus receptor-related protein 1 (Prr1), designated here as HveC. Incubation of HSV-1 with a secreted form of HveC inhibited subsequent infection of a variety of cell lines, suggesting that HveC interacts directly with the virus. Poliovirus receptor (Pvr) itself mediated entry of PRV and BHV-1 but not of the HSV strains tested. HveC was expressed in human cells of epithelial and neuronal origin; it is the prime candidate for the coreceptor that allows both HSV-1 and HSV-2 to infect epithelial cells on mucosal surfaces and spread to cells of the nervous system.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
280
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1618-20
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9616127-Alphaherpesvirinae,
pubmed-meshheading:9616127-Animals,
pubmed-meshheading:9616127-Base Sequence,
pubmed-meshheading:9616127-CHO Cells,
pubmed-meshheading:9616127-Cell Adhesion Molecules,
pubmed-meshheading:9616127-Cells, Cultured,
pubmed-meshheading:9616127-Cricetinae,
pubmed-meshheading:9616127-Epithelial Cells,
pubmed-meshheading:9616127-Gene Expression,
pubmed-meshheading:9616127-Herpesvirus 1, Bovine,
pubmed-meshheading:9616127-Herpesvirus 1, Human,
pubmed-meshheading:9616127-Herpesvirus 1, Suid,
pubmed-meshheading:9616127-Herpesvirus 2, Human,
pubmed-meshheading:9616127-Humans,
pubmed-meshheading:9616127-Membrane Proteins,
pubmed-meshheading:9616127-Molecular Sequence Data,
pubmed-meshheading:9616127-Neurons,
pubmed-meshheading:9616127-Polymerase Chain Reaction,
pubmed-meshheading:9616127-Receptors, Virus,
pubmed-meshheading:9616127-Transfection,
pubmed-meshheading:9616127-Tumor Cells, Cultured,
pubmed-meshheading:9616127-Viral Envelope Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor.
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pubmed:affiliation |
Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, IL 60611, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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