Linked Life Data

9615304

Source:http://linkedlifedata.com/resource/pubmed/id/9615304

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-8-3
pubmed:abstractText
It has been shown that leukocyte adhesion mechanisms play an important role in the development of allergic inflammation in bronchial asthma. We measured the circulating levels of E-selectin (formerly called sElam-1) and intercellular adhesion molecule-1 (ICAM-1) by ELISA in asthmatic subjects. We selected 10 asthmatic subjects to study during an asthma attack, 10 asthmatic subjects in an intercrisis phase, and 20 healthy nonatopic control subjects. A significant increase in the serum levels of soluble E-selectin and soluble ICAM-1 was found in the group of patients during an asthmatic crisis compared to the controls (p < 0.001). The asthmatic patients in an intercrisis phase and the healthy control subjects had overlapping levels of soluble ICAM-1 and soluble E-selectin. The clinical utility of serum soluble levels of adhesion molecules has not been completely assessed and these circulating molecules do not appear to be a useful marker for monitoring the persistent inflammatory activity in stable bronchial asthma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1018-9068
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
105-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Circulating adhesion molecules in bronchial asthma.
pubmed:affiliation
Department of Internal Medicine and Medical Therapeutics, University of Messina, Italy.
pubmed:publicationType
Journal Article