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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1999-5-24
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pubmed:abstractText |
We developed GeneGenerator because of the need for a tool to predict gene structure without knowing in advance how to score potential exons and introns in order to obtain the best results, pertinent in particular to less well-studied organisms for which suitable training sets are small. GeneGenerator is a very flexible algorithm which for a given genomic sequence generates a number of feasible gene structures satisfying user-defined constraints. The specific implementation described in detail requires minimum scoring for translation start and donor and acceptor splice sites according to previously trained logitlinear models. In addition, potential exons and introns are required to exceed specified minimal lengths and threshold scores for coding or non-coding potential derived as log-likelihood ratios of appropriate Markov sequence models.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1367-4803
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
232-43
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9614266-Algorithms,
pubmed-meshheading:9614266-Computational Biology,
pubmed-meshheading:9614266-DNA-Binding Proteins,
pubmed-meshheading:9614266-Exons,
pubmed-meshheading:9614266-Genes, Plant,
pubmed-meshheading:9614266-Glucosyltransferases,
pubmed-meshheading:9614266-Introns,
pubmed-meshheading:9614266-Leucine Zippers,
pubmed-meshheading:9614266-Logistic Models,
pubmed-meshheading:9614266-Markov Chains,
pubmed-meshheading:9614266-Models, Genetic,
pubmed-meshheading:9614266-Plant Proteins,
pubmed-meshheading:9614266-Sequence Analysis, DNA,
pubmed-meshheading:9614266-Software,
pubmed-meshheading:9614266-Software Validation,
pubmed-meshheading:9614266-Transcription Factors,
pubmed-meshheading:9614266-Zea mays
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pubmed:year |
1998
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pubmed:articleTitle |
GeneGenerator--a flexible algorithm for gene prediction and its application to maize sequences.
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pubmed:affiliation |
Freie Universität Berlin, Abteilung Molekularbiologie und Bioinformatik, Institut für Molekularbiologie und Biochemie, Arnimallee 22, 14195 Berlin, Germany. jkleffe@euler.grumed.fu-berlin-de
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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