Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5-6
|
| pubmed:dateCreated |
1998-7-22
|
| pubmed:abstractText |
The BCL-X gene belongs to the family of BCL-2 homologues and plays an important role in the regulation of programmed cell death (PCD) in normal lymphoid tissues. BCL-X is transcribed into 2 mRNAs through alternative splicing. The protein product of the larger BCL-X mRNA (BCL-XL) functions as a PCD repressor. The second mRNA species, BCL-XS, encodes a protein capable of accelerating cell death. BCL-XL is a potential contributor to the pathogenesis of malignant lymphomas because the BCL-XL isoform is predominantly expressed by the neoplastic cells in the majority of lymphoma cases. This review is focused on the possible influence of BCL-X and other PCD regulatory agents on lymphomagenesis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1042-8194
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
451-8
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading | |
| pubmed:year |
1998
|
| pubmed:articleTitle |
BCL-X and the apoptotic machinery of lymphoma cells.
|
| pubmed:affiliation |
Department of Pathology, INSERM U 119, Institut Paoli-Calmettes, Marseille, France.
|
| pubmed:publicationType |
Journal Article,
Review
|