Linked Life Data

9612843

Source:http://linkedlifedata.com/resource/pubmed/id/9612843

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-8-31
pubmed:abstractText
1. Previous experiments in this laboratory found that striatal [3H]WIN 35428 binding was increased in post mortem specimens from human cocaine users (Little et al, 1993a). Although structurally similar, preliminary studies have suggested that [3H]WIN 35428 and the related cocaine congener [125I]RTI-55 differ in some respects pharmacologically. 2. The present experiments tested the hypothesis that striatal [125I]RTI-55 binding would be increased, as was [3H]WIN 35428 binding, in post mortem specimens from cocaine users compared to matched controls. 3. However, computer-generated parameters derived from saturation experiments found only trends toward increased Bmax and decreased affinity (increased KD) in the cocaine users. The magnitude of the increases were notably smaller than the statistically significant increases previously found in high affinity [3H]WIN 35428 binding in these same subjects. 4. Evidence from the present and earlier experiments suggests that cocaine exposure may induce conformational changes in the dopamine transporter.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0278-5846
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
455-66
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Striatal [125I]RTI-55 binding sites in cocaine-abusing humans.
pubmed:affiliation
Department of Psychiatry, University of Michigan, Ann Arbor, USA. kylittle@umich.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.