Linked Life Data

9612377

Source:http://linkedlifedata.com/resource/pubmed/id/9612377

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Pt 2
pubmed:dateCreated
1998-6-24
pubmed:abstractText
The objective of the present study was to determine whether the increase in plasma volume (PV) during pregnancy is established by fluid retention or by a shift within the extracellular fluid volume (ECFV) from the interstitium toward the intravascular compartment. To this end, we simultaneously, measured total body water, (TBW), ECFV, and PV together with the hematocrit (Hct) and plasma osmolality 4, 8, and 12 days postsurgery in chronically instrumented pregnant (P) and nonpregnant (NP) rats. The P rats were instrumented with a catheter in the femoral artery on day 1 postconception. In the NP group, neither TBW nor ECFV and PV had changed consistently on days 8 and 12 postsurgery relative to day 4. In contrast, in the P animals, TBW, ECFV, and PV had increased by 16, 24, and 20%, respectively, by day 12 relative to day 4. To evaluate whether PV had increased in concert with an overall rise in TBW or as a result of a fluid shift at the cost of the interstitial fluid volume, we calculated the relative size of each fluid compartment on three consecutive measurement sessions. In the NP group, TBW, presented as percentage of maternal weight (%MW) as well as ECFV (%TBW) and PV (%ECFV) had not changed consistently throughout the measurement period. In the P animals, TBW (%MW) was slightly higher on day 12 compared with day 4, but ECFV (%TBW) and PV (%ECFV) had not changed significantly. Finally, in the NP group, Hct had not changed, whereas, in the P animals, Hct was 10% lower on days 8 and 12 compared with day 4. Plasma osmolality did not change consistently in either group during the course of the experimental period. The gradual synchronous increase in all fluid compartments, without consistent change in their relative distribution, suggests that, in normal rat pregnancy, PV expansion is primarily achieved by fluid retention rather than by a redistribution of the ECFV.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
274
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
H1662-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Mechanism of volume adaptation in the awake early pregnant rat.
pubmed:affiliation
Department of Obstetrics and Gynecology, Universiteit Maastricht, The Netherlands.
pubmed:publicationType
Journal Article