Linked Life Data

9609798

Source:http://linkedlifedata.com/resource/pubmed/id/9609798

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-7-7
pubmed:abstractText
This study tested the hypothesis that an isometric resistance-training program induces upregulation of slow myosin heavy chain (MHC) expression in a fast-twitch skeletal muscle. Thus we studied the effects of two resistance-training programs on rodent medial gastrocnemius (MG) muscle that were designed to elicit repetitive isometric contractions (10-12 per set; 4 sets per session) of different duration (8 vs. 5 s) and activation frequency (100 vs. 60 Hz) per contraction during each training session (total of 6 and 12 sessions). Results showed that both training paradigms produced significant increases in muscle weight ( approximately 11-13%) after completion of training (P < 0.05). Significant transformations in MHC expression occurred and involved specifically a decrease in the relative expression of the fast type IIb MHC and concomitant increased expression of the fast type IIx MHC. These adaptations were observed in both the "white" and "red" regions of the MG, and they occurred at both the mRNA and protein levels. These adaptations were detected after only six training sessions. Neither of the training programs produced any change in the relative expression of either the slow type I MHC or the moderately fast type IIa MHC, which can be upregulated in the red MG by chronic functional overload. These findings show that the isometric protocols used in this investigation were not sufficient to induce the hypothesized changes in the myosin heavy chain isoform expression in rodent skeletal muscle.
pubmed:grant
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
8750-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2036-41
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Effects of isometric training on skeletal myosin heavy chain expression.
pubmed:affiliation
Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.