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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6 Pt 1
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pubmed:dateCreated |
1998-8-6
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pubmed:abstractText |
The collectins are a class of collagenous lectin proteins present in serum and pulmonary secretions [pulmonary surfactant protein (SP) A and SP-D] that are believed to participate in innate immune responses to various pathogens. With the use of flow cytometric and fluorescent-microscopic assays, SP-A and SP-D were shown to increase calcium-dependent neutrophil uptake of Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus. Evidence is provided that the collectins enhanced bacterial uptake through a mechanism that involved both bacterial aggregation and direct actions on neutrophils. The degree of multimerization of SP-D preparations was a critical determinant of both aggregating activity and potency in enhancing bacterial uptake. The mechanisms of opsonizing activity of SP-D and SP-A differed in important respects from those of opsonizing antibodies. These results provide the first evidence that surfactant collectins may promote neutrophil-mediated clearance of bacteria in the lung independently of opsonizing antibody.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0002-9513
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
274
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
L958-69
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9609735-Animals,
pubmed-meshheading:9609735-Bacteria,
pubmed-meshheading:9609735-Blood Bactericidal Activity,
pubmed-meshheading:9609735-Escherichia coli,
pubmed-meshheading:9609735-Glycoproteins,
pubmed-meshheading:9609735-Humans,
pubmed-meshheading:9609735-Macromolecular Substances,
pubmed-meshheading:9609735-Neutrophils,
pubmed-meshheading:9609735-Opsonin Proteins,
pubmed-meshheading:9609735-Phagocytosis,
pubmed-meshheading:9609735-Proteolipids,
pubmed-meshheading:9609735-Pulmonary Surfactant-Associated Protein A,
pubmed-meshheading:9609735-Pulmonary Surfactant-Associated Protein D,
pubmed-meshheading:9609735-Pulmonary Surfactant-Associated Proteins,
pubmed-meshheading:9609735-Pulmonary Surfactants,
pubmed-meshheading:9609735-Rats,
pubmed-meshheading:9609735-Recombinant Proteins,
pubmed-meshheading:9609735-Staphylococcus aureus,
pubmed-meshheading:9609735-Streptococcus pneumoniae
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pubmed:year |
1998
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pubmed:articleTitle |
Pulmonary surfactant proteins A and D enhance neutrophil uptake of bacteria.
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pubmed:affiliation |
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
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pubmed:publicationType |
Journal Article
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