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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
1998-7-23
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pubmed:abstractText |
The hypothesis of the feasibility of one-point in vivo calibration of intravenously implanted glucose sensors during periods of rapid rise and decline of venous blood glucose concentration was tested. Miniature (5 x 10(-4) cm2 mass transporting area) glucose electrodes with 10-90% response times < 2 min, that did not consume oxygen, were implanted in jugular veins of systemically heparinized rats and used in 4-h experiments, during which the blood glucose concentration was amperometrically monitored. The glucose electrodes were made by electrically connecting ("wiring") reaction centers of glucose oxidase through an electron-conducting redox hydrogel to gold electrode surfaces. The redox polymer and enzyme constituting the electrode sensing layer were immobilized by cross-linking, and thus the electrodes had no diffusional and readily leached redox mediator. One hour after their implantation, the electrodes accurately tracked the blood glucose concentration when calibrated in vivo by a one-point calibration, when the glucose concentration was steady, when rising rapidly, and when declining steeply. For an assumed 2-min lag time, the sensor readings were well correlated with the true blood glucose concentrations, with linear regression analysis yielding a slope of 0.97 +/- 0.07 and an intercept (bias) of 0.3 +/- 0.3 mM. The correlation coefficient, r2, was 0.949 +/- 0.020, and the percent difference through the 2-22 mM range was 1.9 +/- 1.0%. The results suggest that, in combination with understanding and modeling of transient physiological differences between the subcutaneous and the blood glucose concentrations, it will be possible to calibrate by one-point in vivo calibration subcutaneously implanted sensors, even while the glucose concentration changes rapidly.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antifibrinolytic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Gels,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Gold,
http://linkedlifedata.com/resource/pubmed/chemical/Heparin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0003-2700
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2149-55
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9608851-Animals,
pubmed-meshheading:9608851-Antifibrinolytic Agents,
pubmed-meshheading:9608851-Biosensing Techniques,
pubmed-meshheading:9608851-Blood Glucose,
pubmed-meshheading:9608851-Calibration,
pubmed-meshheading:9608851-Electrodes, Implanted,
pubmed-meshheading:9608851-Feasibility Studies,
pubmed-meshheading:9608851-Gels,
pubmed-meshheading:9608851-Glucose Oxidase,
pubmed-meshheading:9608851-Gold,
pubmed-meshheading:9608851-Heparin,
pubmed-meshheading:9608851-Jugular Veins,
pubmed-meshheading:9608851-Linear Models,
pubmed-meshheading:9608851-Male,
pubmed-meshheading:9608851-Oxidation-Reduction,
pubmed-meshheading:9608851-Rats,
pubmed-meshheading:9608851-Rats, Sprague-Dawley,
pubmed-meshheading:9608851-Sensitivity and Specificity
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pubmed:year |
1998
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pubmed:articleTitle |
Accuracy of the one-point in vivo calibration of "wired" glucose oxidase electrodes implanted in jugular veins of rats in periods of rapid rise and decline of the glucose concentration.
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pubmed:affiliation |
Department of Chemical Engineering, University of Texas at Austin 78712-1062, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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