Linked Life Data

9608575

Source:http://linkedlifedata.com/resource/pubmed/id/9608575

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-7-20
pubmed:abstractText
The regional cerebral metabolic rates of 19 male medication-withdrawn schizophrenic patients were determined by positron emission tomography (PET) while performing an auditory discrimination task (CPT). Regardless of the accuracy of their CPT performance, the schizophrenic patients had lower metabolic rates in their prefrontal cortex and higher rates in their posterior putamen compared to 41 healthy males. Abnormally low right anterior midprefrontal cortex metabolic rates predicted better clinical response while high basal ganglia rates and low mid-cingulate rates predicted poor treatment response to neuroleptics. The findings imply that the sustained attention pathway and its distributed network of brain structures are likely to play an important role in the expression of psychotic symptoms and the mediation of their response to antipsychotics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0893-133X
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
36-47
pubmed:dateRevised
2011-5-18
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Abnormalities in the distributed network of sustained attention predict neuroleptic treatment response in schizophrenia.
pubmed:affiliation
Section on Clinical Brain Imaging, National Institute of Mental Health, Bethesda, MD 20892-4030, USA.
pubmed:publicationType
Journal Article