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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-6-18
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pubmed:abstractText |
The persistence of humoral and cellular immunity to varicella-zoster virus (VZV) was evaluated in 60 children and 18 adults immunized with live attenuated VZV vaccine. At a mean of 5 years after vaccination, 93% of children and 94% of adults had IgG antibodies to VZV as determined by ELISA. VZV antibody concentrations were significantly higher at 5 years than at 1 year after immunization in children and adults. Cell-mediated immunity to VZV was detected in 87% of children and 94% of adults at 5 years. The mean stimulation index was significantly higher at 5 years than at 1 year among children and adults. Cytokine responses to VZV, including interleukin-2, interferon-gamma, and interleukin-10 were equivalent between children and adults at 5 years. In summary, varicella immunization induced long-term humoral and cellular immunity, and initial differences between cell-mediated responses in children and adults diminished over time.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1899
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1701-4
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9607852-Adolescent,
pubmed-meshheading:9607852-Adult,
pubmed-meshheading:9607852-Antibodies, Viral,
pubmed-meshheading:9607852-Antibody Formation,
pubmed-meshheading:9607852-Cell Division,
pubmed-meshheading:9607852-Chickenpox Vaccine,
pubmed-meshheading:9607852-Child,
pubmed-meshheading:9607852-Child, Preschool,
pubmed-meshheading:9607852-Follow-Up Studies,
pubmed-meshheading:9607852-Humans,
pubmed-meshheading:9607852-Immunity, Cellular,
pubmed-meshheading:9607852-Immunoglobulin G,
pubmed-meshheading:9607852-Interferon-gamma,
pubmed-meshheading:9607852-Interleukin-10,
pubmed-meshheading:9607852-Interleukin-2,
pubmed-meshheading:9607852-Middle Aged,
pubmed-meshheading:9607852-T-Lymphocytes,
pubmed-meshheading:9607852-Vaccination,
pubmed-meshheading:9607852-Vaccines, Attenuated
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pubmed:year |
1998
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pubmed:articleTitle |
Analysis of the persistence of humoral and cellular immunity in children and adults immunized with varicella vaccine.
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pubmed:affiliation |
Department of Pediatrics, Stanford University School of Medicine, California 94305-5208, USA. zerboni@leland.stanford.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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