Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-8-3
pubmed:abstractText
Major histocompatibility complex (MHC) determinants control antibody production in response to protein antigens. Vaccination with hepatitis B surface antigen (HBsAg) frequently fails in hemodialyzed patients, but the genetic factors that modulate humoral responsiveness are poorly characterized. We studied the distribution of HLA class II alleles in 415 hemodialyzed Caucasian patients who received a full course of HBsAg vaccination, using class II oligotyping after genomic amplification of the DRB1 and DQB1 loci. Phenotype frequencies were compared in 114 non responders (anti-HBs antibodies < or = 10 SI units/liter), 301 responders (anti-HBs antibodies > 10 units/liter) and 471 healthy controls. DRB1*01 (DR1) and DRB1*15 (DR15) frequencies were lower in nonresponders than in responders and controls (DR1, 12.3% vs. 22.9% and 24.8%, respectively; DR15, 14% vs. 22.9% and 25.1%), while DRB1*03 (DR3) and DRB1*14 (DR14) frequencies were higher (DR3, 32.5% vs. 16.6% and 25.3%, respectively; DR14, 9.6% vs. 3% and 6.6%). Overall, 44.5% of DR3 or DR14 patients were nonresponders, compared to 18.1% of DR1 or DR15 patients (P = 0.0001). In conclusion the humoral response to HBsAg vaccine is influenced by class II allelic variants, which differ in their capacity to bind and present peptides to T lymphocytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0085-2538
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1626-30
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:9607193-Alleles, pubmed-meshheading:9607193-Antibody Formation, pubmed-meshheading:9607193-Female, pubmed-meshheading:9607193-Gene Frequency, pubmed-meshheading:9607193-HLA-DQ Antigens, pubmed-meshheading:9607193-HLA-DQ beta-Chains, pubmed-meshheading:9607193-HLA-DR Antigens, pubmed-meshheading:9607193-HLA-DRB1 Chains, pubmed-meshheading:9607193-Hepatitis B, pubmed-meshheading:9607193-Hepatitis B Antibodies, pubmed-meshheading:9607193-Hepatitis B Surface Antigens, pubmed-meshheading:9607193-Hepatitis B virus, pubmed-meshheading:9607193-Histocompatibility Antigens Class II, pubmed-meshheading:9607193-Humans, pubmed-meshheading:9607193-Male, pubmed-meshheading:9607193-Middle Aged, pubmed-meshheading:9607193-Phenotype, pubmed-meshheading:9607193-Vaccination, pubmed-meshheading:9607193-Viral Vaccines
pubmed:year
1998
pubmed:articleTitle
Distinct HLA class II alleles determine antibody response to vaccination with hepatitis B surface antigen.
pubmed:affiliation
Laboratory of Immunology, Hôpital Necker, Paris, France. caillat@necker.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't