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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0008633,
umls-concept:C0009015,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0079429,
umls-concept:C0086418,
umls-concept:C0332183,
umls-concept:C0345904,
umls-concept:C0475264,
umls-concept:C0675121,
umls-concept:C1334043,
umls-concept:C1366509,
umls-concept:C1553877,
umls-concept:C1608885,
umls-concept:C1880022,
umls-concept:C1880274
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pubmed:issue |
10
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pubmed:dateCreated |
1998-6-10
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pubmed:databankReference | |
pubmed:abstractText |
The isolation of genes involved in cancer development is critical for uncovering the molecular basis of cancer. We report here the isolation of the full-length cDNA and chromosomal localization of a new gene frequently deleted in liver cancer (DLC-1) that was identified by representational difference analysis. Loss of heterozygosity was detected for DLC-1 in 7 of 16 primary hepatocellular carcinomas (HCCs) and in 10 of 11 HCC cell lines. Although mRNA for DLC-1 was expressed in all normal human tissues, it was not expressed in 4 of 14 HCC cell lines. Full-length cDNA for DLC-1 of 3800 bp encodes a protein of 1091 amino acids, has 86% homology with rat p122 RhoGAP gene, and was localized by fluorescence in situ hybridization on chromosome 8 at bands p21.3-22. Deletions on the short arm of chromosome 8 are recurrent in liver, breast, lung, and prostate cancers, suggesting the presence of tumor suppressor genes. DLC-1 may be a tumor suppressor gene in liver cancer as well as in other cancers.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0008-5472
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2196-9
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pubmed:dateRevised |
2011-10-3
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pubmed:meshHeading |
pubmed-meshheading:9605766-Animals,
pubmed-meshheading:9605766-Carcinoma, Hepatocellular,
pubmed-meshheading:9605766-Chromosome Mapping,
pubmed-meshheading:9605766-Chromosomes, Human, Pair 8,
pubmed-meshheading:9605766-GTPase-Activating Proteins,
pubmed-meshheading:9605766-Gene Deletion,
pubmed-meshheading:9605766-Genes, Tumor Suppressor,
pubmed-meshheading:9605766-Humans,
pubmed-meshheading:9605766-Liver Neoplasms,
pubmed-meshheading:9605766-Loss of Heterozygosity,
pubmed-meshheading:9605766-Molecular Sequence Data,
pubmed-meshheading:9605766-Proteins,
pubmed-meshheading:9605766-Rats,
pubmed-meshheading:9605766-Tumor Cells, Cultured,
pubmed-meshheading:9605766-Tumor Suppressor Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP.
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pubmed:affiliation |
Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA.
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pubmed:publicationType |
Journal Article
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