Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1998-6-11
|
| pubmed:abstractText |
Hyperthermic stress induces reactivation of herpes simplex virus type 1 (HSV-1) in latently infected mice and also stimulates corticosterone release from the adrenals via activation of the hypothalamic pituitary adrenal axis. In the present study, we tested the hypothesis that stress-induced elevation of corticosterone potentiates HSV-1 reactivation in latently infected mice. Because of the putative role of IL-6 in facilitating HSV-1 reactivation in mice, the effect of hyperthermic stress and cyanoketone treatment on IL-6 expression in the trigeminal ganglion was also measured. Preadministration of cyanoketone, a glucocorticoid synthesis inhibitor, blocked the stress-induced elevation of corticosterone in a dose-dependent manner. Furthermore, inhibition of corticosterone synthesis was correlated with reduced levels of HSV-1 reactivation in latently infected mice. Hyperthermic stress elicited a transient rise in IL-6 mRNA levels in the trigeminal ganglion, but not other cytokine transcripts investigated. In addition, there was a significant reduction in MAC-3+, CD8+, and DX5+ (NK cell marker) cells in the trigeminal ganglion of latent HSV-1-infected mice 24 h after stress. Cyanoketone blocked the stress-induced rise in IL-6 mRNA and protein expression in the trigeminal ganglion latently infected with HSV-1. Collectively, the results indicate that the activation of the hypothalamic pituitary adrenal axis plays an important role in stimulating IL-6 expression and HSV-1 reactivation in the trigeminal ganglion following hyperthermic stress of mice.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Corticosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Cyanoketone,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/monocyte-macrophage...
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
160
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
5441-7
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9605146-Animals,
pubmed-meshheading:9605146-Antigens, CD8,
pubmed-meshheading:9605146-Antigens, Differentiation,
pubmed-meshheading:9605146-Corticosterone,
pubmed-meshheading:9605146-Cyanoketone,
pubmed-meshheading:9605146-Female,
pubmed-meshheading:9605146-Herpes Simplex,
pubmed-meshheading:9605146-Herpesvirus 1, Human,
pubmed-meshheading:9605146-Hyperthermia, Induced,
pubmed-meshheading:9605146-Hypothalamo-Hypophyseal System,
pubmed-meshheading:9605146-Interleukin-6,
pubmed-meshheading:9605146-Killer Cells, Natural,
pubmed-meshheading:9605146-Macrophages,
pubmed-meshheading:9605146-Mice,
pubmed-meshheading:9605146-Mice, Inbred Strains,
pubmed-meshheading:9605146-Pituitary-Adrenal System,
pubmed-meshheading:9605146-RNA, Messenger,
pubmed-meshheading:9605146-Stress, Physiological,
pubmed-meshheading:9605146-Transcription, Genetic,
pubmed-meshheading:9605146-Trigeminal Ganglion,
pubmed-meshheading:9605146-Virus Activation,
pubmed-meshheading:9605146-Virus Latency
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Role of the hypothalamic pituitary adrenal axis and IL-6 in stress-induced reactivation of latent herpes simplex virus type 1.
|
| pubmed:affiliation |
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans 70112, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|