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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-6-5
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pubmed:abstractText |
AP-2 is a vertebrate transcription factor expressed in neural crest cells and their derivative tissues, including the adrenal medulla, where epinephrine is produced. AP-2 is shown to stimulate expression of the gene encoding the epinephrine biosynthetic enzyme phenylethanolamine N-methyltransferase (PNMT). However, stimulation of the PNMT gene by AP-2 requires glucocorticoids and appears to be mediated through the interaction of AP-2 with activated type II glucocorticoid receptors. Mutation of AP-2 and/or glucocorticoid receptor binding elements within the PNMT promoter disrupts the ability of AP-2 and glucocorticoids to induce PNMT promoter activity. These findings suggest, in the case of PNMT, that AP-2 stimulates gene expression through a novel glucocorticoid-dependent mechanism.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-3042
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2286-95
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9603193-Adrenal Medulla,
pubmed-meshheading:9603193-Animals,
pubmed-meshheading:9603193-Binding Sites,
pubmed-meshheading:9603193-Cell Line,
pubmed-meshheading:9603193-Chromaffin Cells,
pubmed-meshheading:9603193-DNA-Binding Proteins,
pubmed-meshheading:9603193-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:9603193-Genetic Vectors,
pubmed-meshheading:9603193-Glucocorticoids,
pubmed-meshheading:9603193-Mice,
pubmed-meshheading:9603193-Mutation,
pubmed-meshheading:9603193-Phenylethanolamine N-Methyltransferase,
pubmed-meshheading:9603193-Promoter Regions, Genetic,
pubmed-meshheading:9603193-Rats,
pubmed-meshheading:9603193-Rats, Sprague-Dawley,
pubmed-meshheading:9603193-Receptors, Glucocorticoid,
pubmed-meshheading:9603193-Transcription Factor AP-2,
pubmed-meshheading:9603193-Transcription Factors,
pubmed-meshheading:9603193-Transfection
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pubmed:year |
1998
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pubmed:articleTitle |
Glucocorticoid-dependent action of neural crest factor AP-2: stimulation of phenylethanolamine N-methyltransferase gene expression.
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pubmed:affiliation |
Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305-5485, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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