Linked Life Data

9601992

Source:http://linkedlifedata.com/resource/pubmed/id/9601992

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-7-9
pubmed:databankReference
pubmed:abstractText
Members of the NK-2 homeobox gene family are expressed in distinct parts of the central nervous system and in other non-neural territories not only in the fruitfly Drosophila melanogaster, but also in vertebrates. The murine Nkx2.1 (TTF-1, T/ebp) gene was previously shown to be active and indispensable in the developing forebrain, hypophysis, thyroid and lung. Here we report the early transcript distribution of the chick NKX2.1 gene. By whole-mount in situ hybridization we detect a novel transient expression domain in the early epiblast. Further expression occurs in the ventral medial endoderm, which becomes restricted to the anlage fields of the thyroid and lung, in the ventral diencephalon and telencephalon. These findings suggest that NKX2.1 is part of a Nkx code which specifies ventral territories in the vertebrate embryo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0949-944X
pubmed:author
pubmed:issnType
Print
pubmed:volume
208
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
168-71
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Demarcation of ventral territories by the homeobox gene NKX2.1 during early chick development.
pubmed:affiliation
Max-Planck-Institut für biophysikalische Chemie, D-37077 Göttingen, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't