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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-8-13
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pubmed:abstractText |
Alpha-synuclein has been implicated in the pathogenesis of Parkinson's disease. To investigate the role of alpha-synuclein in the brain, the cDNA clone encoding the mouse cognate of the human alpha-synuclein was isolated from a mouse brain cDNA library. The open reading frame coded for 140 amino acids that share 95% identity with human alpha-synuclein. Northern blot analysis showed that alpha-synuclein mRNA was primarily expressed in brain and spleen of adult mouse. In situ hybridization histochemistry revealed the highest expression of alpha-synuclein mRNA in the hippocampal formation and neocortex of the adult mouse. alpha-Synuclein mRNA expression in the brain was first observed in the hippocampus and neocortex on postnatal day 1. Levels of alpha-synuclein mRNA in these forebrain areas were nearly maximal at postnatal day 7 and remained relatively high until the adult stage. alpha-Synuclein mRNA was expressed in the liver transiently during embryogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/SNCA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Snca protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Synucleins,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Synuclein
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1239-43
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9601701-Amino Acid Sequence,
pubmed-meshheading:9601701-Animals,
pubmed-meshheading:9601701-Base Sequence,
pubmed-meshheading:9601701-Brain,
pubmed-meshheading:9601701-Cloning, Molecular,
pubmed-meshheading:9601701-DNA, Complementary,
pubmed-meshheading:9601701-Genes, Dominant,
pubmed-meshheading:9601701-Humans,
pubmed-meshheading:9601701-Mice,
pubmed-meshheading:9601701-Molecular Sequence Data,
pubmed-meshheading:9601701-Mutation,
pubmed-meshheading:9601701-Nerve Tissue Proteins,
pubmed-meshheading:9601701-Parkinson Disease,
pubmed-meshheading:9601701-Phenotype,
pubmed-meshheading:9601701-RNA, Messenger,
pubmed-meshheading:9601701-Sequence Homology, Nucleic Acid,
pubmed-meshheading:9601701-Synucleins,
pubmed-meshheading:9601701-alpha-Synuclein
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pubmed:year |
1998
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pubmed:articleTitle |
The cDNA cloning and ontogeny of mouse alpha-synuclein.
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pubmed:affiliation |
Department of Molecular Biology Laboratory, Ajou University School of Medicine, Suwon, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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