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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-6-8
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pubmed:abstractText |
The bis-azo compound FP-21399 inhibits HIV-1 infection. We now show that FP-21399 acts on the HIV-1 envelope glycoprotein to prevent viral replication. This compound targets the entry step of the HIV-1 replication cycle as demonstrated by time-of-addition and single cycle viral entry assays. The entry of SIVmac239, which uses the same coreceptors (CD4/CCR5) as HIV-1, was not inhibited by FP-21399, indicating that the antiviral effect of FP-21399 is specific for the HIV-1 envelope glycoprotein and is not dependent upon the cellular receptors CD4 and CCR5. FP-21399 inhibits neither the activity of HIV-1 reverse transcriptase nor the expression of HIV-1 early mRNA. Finally, this compound inhibits gp120 shedding of the T-tropic virus. Our results suggest that the anti-HIV activity of FP-21399 is due to its interaction with HIV-1 gp120/41 complex during viral entry.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-HIV Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/FP 21399,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp41,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0042-6822
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pubmed:author |
pubmed-author:ChenL BLB,
pubmed-author:ChoiLL,
pubmed-author:CrumpackerC SCS,
pubmed-author:DezubeB JBJ,
pubmed-author:FarzanMM,
pubmed-author:GilliesSS,
pubmed-author:OnoMM,
pubmed-author:SharmaP LPL,
pubmed-author:SodroskiJ GJG,
pubmed-author:WuYY,
pubmed-author:ZhangJ LJL,
pubmed-author:ZhouX CXC
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
244
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
530-41
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9601521-Animals,
pubmed-meshheading:9601521-Anti-HIV Agents,
pubmed-meshheading:9601521-Base Sequence,
pubmed-meshheading:9601521-Chlorobenzenes,
pubmed-meshheading:9601521-DNA Primers,
pubmed-meshheading:9601521-Gene Expression,
pubmed-meshheading:9601521-HIV Envelope Protein gp120,
pubmed-meshheading:9601521-HIV Envelope Protein gp41,
pubmed-meshheading:9601521-HIV Infections,
pubmed-meshheading:9601521-HIV-1,
pubmed-meshheading:9601521-Humans,
pubmed-meshheading:9601521-Leukocytes, Mononuclear,
pubmed-meshheading:9601521-Membrane Fusion,
pubmed-meshheading:9601521-Naphthalenes,
pubmed-meshheading:9601521-RNA, Messenger,
pubmed-meshheading:9601521-RNA, Viral,
pubmed-meshheading:9601521-Receptors, CCR5,
pubmed-meshheading:9601521-Receptors, CXCR4,
pubmed-meshheading:9601521-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:9601521-Simian immunodeficiency virus,
pubmed-meshheading:9601521-Virus Replication
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pubmed:year |
1998
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pubmed:articleTitle |
The bis-azo compound FP-21399 inhibits HIV-1 replication by preventing viral entry.
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pubmed:affiliation |
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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