Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1998-6-22
pubmed:abstractText
Loss of neurotransmitter receptors, especially glutamate and dopamine receptors, is one of the pathologic hallmarks of brains of patients with Huntington disease (HD). Transgenic mice that express exon 1 of an abnormal human HD gene (line R6/2) develop neurologic symptoms at 9-11 weeks of age through an unknown mechanism. Analysis of glutamate receptors (GluRs) in symptomatic 12-week-old R6/2 mice revealed decreases compared with age-matched littermate controls in the type 1 metabotropic GluR (mGluR1), mGluR2, mGluR3, but not the mGluR5 subtype of G protein-linked mGluR, as determined by [3H]glutamate receptor binding, protein immunoblotting, and in situ hybridization. Ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and kainate receptors were also decreased, while N-methyl-D-aspartic acid receptors were not different compared with controls. Other neurotransmitter receptors known to be affected in HD were also decreased in R6/2 mice, including dopamine and muscarinic cholinergic, but not gamma-aminobutyric acid receptors. D1-like and D2-like dopamine receptor binding was drastically reduced to one-third of control in the brains of 8- and 12-week-old R6/2 mice. In situ hybridization indicated that mGluR and D1 dopamine receptor mRNA were altered as early as 4 weeks of age, long prior to the onset of clinical symptoms. Thus, altered expression of neurotransmitter receptors precedes clinical symptoms in R6/2 mice and may contribute to subsequent pathology.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-1314341, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-1375315, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-1665055, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-1680055, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-1695405, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-1833662, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-1838580, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-1973276, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-2159128, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-2422561, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-2984415, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-3768686, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-6292789, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-6452910, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-6884434, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-7477379, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-7623957, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-7682857, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-7748554, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-7748555, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-7922497, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-8108544, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-8294904, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-8458085, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-8643490, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-8684387, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-8684625, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-8687191, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-8696339, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-8757264, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-8787136, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-8833437, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-8898202, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-8915584, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-8962095, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-8994886, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-9029064, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-9168825, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-9243620, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-9266732, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-9267033, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-9267034, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-9292723, http://linkedlifedata.com/resource/pubmed/commentcorrection/9600992-9302293
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6480-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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